Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.
Cancer Research Institute, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, Republic of Korea.
Abdom Radiol (NY). 2024 Feb;49(2):406-413. doi: 10.1007/s00261-023-04009-6. Epub 2023 Oct 6.
This retrospective study aimed to evaluate the validity of an automated screening Dixon (e-DIXON) technique for quantifying hepatic steatosis in living liver-donor patients by comparison with magnetic resonance spectroscopy (MRS) as a reference standard.
A total of 285 living liver-donor candidates were examined with the e-DIXON technique and single-voxel MRS to assess hepatic steatosis and iron deposition between January 2014 and February 2019. The sensitivity, specificity, and positive and negative predictive values (PPV and NPV) of the e-DIXON technique for hepatic steatosis were calculated. The mean fat signal fractions obtained in MRS were compared between the donors diagnosed with hepatic steatosis and the normal group. The mean R2 values of donors with or without hepatic siderosis also were compared.
The e-DIXON technique diagnosed normal in 133 (47%), fat in 124 (44%), iron in one (0.4%), and a combination of both fat and iron in 27 (10%) donors. The sensitivity, specificity, PPV, and NPV for diagnosing hepatic steatosis were 94%, 70%, 64%, and 96%, respectively. There was a significant difference in the mean fat signal fraction obtained in MRS between the steatosis and normal groups (p < 0.001), but R2 values were not significantly different between siderosis and normal groups (p = 0.11). The e-DIXON technique showed a strong correlation with MRS in fat measurement (r = 0.92, p < 0.001).
The e-DIXON technique reliably screens for hepatic steatosis but may not accurate for detecting hepatic iron deposition.
本回顾性研究旨在通过与磁共振波谱（MRS）作为参考标准比较，评估自动 Dixon（e-DIXON）技术定量活体肝供体患者肝脂肪变性的有效性。
2014 年 1 月至 2019 年 2 月，共对 285 例活体肝供体候选者进行 e-DIXON 技术和单体素 MRS 检查，以评估肝脂肪变性和铁沉积。计算 e-DIXON 技术诊断肝脂肪变性的敏感性、特异性、阳性预测值（PPV）和阴性预测值（NPV）。比较 MRS 检测到的肝脂肪变性供体与正常组的平均脂肪信号分数。还比较了有或无肝 siderosis 的供体的平均 R2 值。
e-DIXON 技术诊断 133 例（47%）为正常，124 例（44%）为脂肪，1 例（0.4%）为铁，27 例（10%）为脂肪和铁混合。诊断肝脂肪变性的敏感性、特异性、PPV 和 NPV 分别为 94%、70%、64%和 96%。MRS 获得的平均脂肪信号分数在脂肪变性组和正常组之间存在显著差异（p < 0.001），但 siderosis 组和正常组之间的 R2 值无显著差异（p = 0.11）。e-DIXON 技术在脂肪测量方面与 MRS 具有很强的相关性（r = 0.92，p < 0.001）。
e-DIXON 技术可靠地筛查肝脂肪变性，但可能无法准确检测肝铁沉积。
