运动对心力衰竭患者端粒长度的影响。
The Effects of Exercise on Telomere Length in Persons With Heart Failure.
出版信息
J Cardiovasc Nurs. 2024;39(3):E86-E92. doi: 10.1097/JCN.0000000000001044. Epub 2023 Oct 6.
BACKGROUND
Telomere length is reduced in persons with heart failure (HF). Inflammation is a putative mechanism contributing to telomere shortening. Although physical activity is known to increase telomere length, its effects in HF are unknown.
OBJECTIVE
The aim of this study was to examine the effects of exercise on telomere length and its relationship with interleukin (IL)-1β in persons with HF.
METHODS
This secondary analysis of a 3-month home-based aerobic exercise intervention measured total telomere length and IL-1β levels in persons with HF (69% with reduced ejection fraction).
RESULTS
Total telomere length increased and plasma IL-1β levels decreased in the exercise group from baseline to 3 months. Total telomere length was negatively associated with IL-1β at baseline ( r = -0.441 P = .001).
CONCLUSIONS
The association between telomere length and IL-1β suggests a relationship between inflammation and cellular aging. Moderate-intensity exercise may help maintain cellular functions. Further research is needed to examine the effects on outcomes in persons with HF.
背景
心力衰竭（HF）患者的端粒长度会缩短。炎症是导致端粒缩短的一个假定机制。虽然已知体力活动可以增加端粒长度，但它在 HF 中的作用尚不清楚。
目的
本研究旨在探讨运动对 HF 患者端粒长度的影响及其与白细胞介素（IL）-1β的关系。
方法
对为期 3 个月的家庭有氧运动干预的二次分析测量了 HF 患者（射血分数降低者占 69%）的总端粒长度和 IL-1β 水平。
结果
从基线到 3 个月，运动组的总端粒长度增加，血浆 IL-1β 水平下降。总端粒长度与基线时的 IL-1β呈负相关（r=-0.441，P=0.001）。
结论
端粒长度与 IL-1β之间的关联表明炎症与细胞衰老之间存在关系。中等强度的运动可能有助于维持细胞功能。需要进一步研究运动对 HF 患者结局的影响。
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