Jiang Yan-Hua, Qian Zhen-Zhen, Zhu Jian, Wu Guang, Wu Hong-Li, Jing Zhi-Wei
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences Beijing 100700, China.
Postdoctoral Research Station, China Academy of Chinese Medical Sciences Beijing 100700, China.
Zhongguo Zhong Yao Za Zhi. 2023 Sep;48(18):5102-5112. doi: 10.19540/j.cnki.cjcmm.20230530.501.
In this study, the evidence map system was used to sort out the clinical research evidence on traditional Chinese medicine(TCM) treatment of vertigo and understand the evidence distribution in this field. CNKI, Wanfang, VIP, SinoMed, PubMed, EMbase, and Web of Science were searched for the clinical randomized controlled trial(RCT) and systematic reviews/Meta-analysis on TCM treatment of vertigo in recent five years, and the evidence was analyzed and presented in the form of text and charts. The Cochrane handbook for systematic reviews of interventions was used to evaluate the quality of the clinical RCT, and the AMSTAR mea-surement tool was used to evaluate the quality of the systematic reviews/Meta-analysis. A total of 382 RCTs and eight systematic reviews/Meta-analysis were included. In recent five years, the number of published articles has been on the rise. There were many intervention measures and TCM therapies for vertigo. Outcome indicators mainly included clinical efficacy, TCM syndrome score, vertigo score, occurrence of adverse reactions, and effective rate. The overall quality of clinical RCT and systematic reviews/Meta-analysis was low. Most studies have proven the potential efficacy of TCM in treating vertigo, but there was still no clear clinical evidence of efficacy. The results show that TCM has advantages in the treatment of vertigo, but there are also problems. More high-quality studies are still lacking, suggesting that more large-sample and multi-center RCT should be conducted in the future, and the quality of relevant syste-matic reviews/Meta-analysis should be improved to fully explore the advantages of TCM in the treatment of vertigo, and provide strong support for the effectiveness and safety of TCM in the treatment of vertigo.
在本研究中，采用证据图谱系统梳理中医治疗眩晕的临床研究证据，了解该领域的证据分布情况。检索了中国知网、万方、维普、中国生物医学文献数据库、PubMed、EMbase和Web of Science，查找近五年中医治疗眩晕的临床随机对照试验（RCT）和系统评价/Meta分析，并以文本和图表形式对证据进行分析和呈现。采用《Cochrane干预措施系统评价手册》评估临床RCT的质量，采用AMSTAR测量工具评估系统评价/Meta分析的质量。共纳入382项RCT和8项系统评价/Meta分析。近五年发表的文章数量呈上升趋势。眩晕的干预措施和中医疗法众多。结局指标主要包括临床疗效、中医证候评分、眩晕评分、不良反应发生情况及有效率。临床RCT和系统评价/Meta分析的整体质量较低。大多数研究已证实中医治疗眩晕具有潜在疗效，但仍缺乏明确的临床疗效证据。结果表明，中医在眩晕治疗方面具有优势，但也存在问题。仍缺乏更多高质量研究，提示未来应开展更多大样本、多中心RCT，并提高相关系统评价/Meta分析的质量，以充分发掘中医在眩晕治疗中的优势，为中医治疗眩晕的有效性和安全性提供有力支持。
