Borlenghi E, Roccaro A M, Cattaneo C
Hematology, ASST Spedali Civili, Brescia, Italy.
Clinical Trial Center, Translational Research and Phase I Unit, ASST Spedali Civili, Brescia, Italy.
Br J Haematol. 2023 Nov;203(4):504-506. doi: 10.1111/bjh.19138. Epub 2023 Oct 6.
Invasive fungal infections (IFIs), mainly due to pulmonary aspergillosis, are considered a serious complication in acute leukaemia, with an unfavourable impact on patient. In this well-conducted retrospective study, Reynolds et al. suggest that the use of posaconazole prophylaxis in association with venetoclax plus hypomethylating agents or chemotherapy leads to a reduction of IFI incidence. Therapeutic drug monitoring of posaconazole levels is suggested, even if no correlation with IFI risk has been demonstrated. Commentary on: Reynolds et al. Invasive fungal infection following venetoclax and posaconazole co-administration. Br J Haematol 2023;203:593-598.
侵袭性真菌感染（IFI）主要由肺曲霉病引起，被认为是急性白血病的一种严重并发症，对患者有不利影响。在这项精心实施的回顾性研究中，雷诺兹等人表明，泊沙康唑预防联合维奈托克加去甲基化药物或化疗可降低IFI的发生率。即使尚未证明泊沙康唑水平与IFI风险之间存在相关性，仍建议对泊沙康唑水平进行治疗药物监测。评论：雷诺兹等人。维奈托克和泊沙康唑联合给药后的侵袭性真菌感染。《英国血液学杂志》2023年；203:593 - 598。
