The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel-Hashomer, Israel.
Department of Psychiatry, The Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Int J Geriatr Psychiatry. 2023 Oct;38(10):e6011. doi: 10.1002/gps.6011.
The likelihood of depression symptoms in those with type 2 diabetes (T2D) is high. Psychological risk factors enhancing comorbidity of depression symptoms in T2D are yet to be determined. The present study examines the cross-sectional and longitudinal relationship between personality traits and distinct depression dimensions in older adults with T2D.
Participants were older adults (age ≥65yeas) with T2D from the Israel Diabetes and Cognitive Decline (IDCD) study (N = 356), with complete data on depression [Geriatric Depression Scale (GDS) - 15 item version] and its dimensions- namely, dysphoric mood, apathy, hopelessness, memory complains and anxiety, and on personality [Big Five Inventory (BFI)]. Logistic and mixed linear regression models examined cross-sectional and longitudinal associations while adjusting for socio-demographics, cognition, cardiovascular and diabetes-related factors.
Cross-sectionally, high neuroticism was associated with high scores in total GDS and in all depression-dimensions, except memory complaints. Higher extroversion was associated with lower total GDS and with lower scores on all depression dimensions, except anxiety. High levels of neuroticism were associated with increase in total number of depression symptoms over time.
In older adults with T2D, neuroticism and extroversion are associated with most depression dimensions suggesting that these traits relate to a global depression symptomatology rather than to any specific dimension or phenomenology. High neuroticism was associated with increase in depression symptoms over time, highlighting its role in the development of depression symptoms in older adults with T2D.
患有 2 型糖尿病（T2D）的人出现抑郁症状的可能性很高。增强 T2D 患者抑郁症状共病的心理风险因素仍有待确定。本研究旨在探讨老年 T2D 患者的人格特质与不同抑郁维度之间的横断面和纵向关系。
参与者为来自以色列糖尿病和认知衰退（IDCD）研究的老年 T2D 患者（年龄≥65 岁）（N=356），他们在抑郁方面有完整的数据[老年抑郁量表（GDS）-15 项版本]及其维度，即抑郁情绪、淡漠、绝望、记忆力减退和焦虑，以及人格[大五人格量表（BFI）]。逻辑和混合线性回归模型在调整社会人口统计学、认知、心血管和糖尿病相关因素后，检查了横断面和纵向关联。
横断面研究显示，神经质与 GDS 总分和除记忆力减退外的所有抑郁维度的高分相关。外向性与 GDS 总分和除焦虑外的所有抑郁维度的低分相关。神经质水平较高与抑郁症状总数随时间增加有关。
在老年 T2D 患者中，神经质和外向性与大多数抑郁维度相关，这表明这些特质与整体抑郁症状有关，而不是与任何特定的维度或表现有关。神经质水平较高与抑郁症状随时间增加有关，突出了其在老年 T2D 患者抑郁症状发展中的作用。
