Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
J Infect Dis. 2024 Jun 14;229(6):1845-1855. doi: 10.1093/infdis/jiad426.
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with significant mortality. Identifying prognostic factors that influence patient outcomes is crucial for effective clinical management. In this study, we assessed the dynamic changes of laboratory markers and their association with outcomes in 93 SFTS patients. We found that age and hypertension were significantly associated with poor outcomes in SFTS patients. The deceased group exhibited lower platelet counts, elevated liver and kidney function markers, coagulation profiles, inflammatory markers, and cytokines compared to the survival group. Kinetic analysis showed that these markers gradually normalized in the survival group, while they remained persistently abnormal in the deceased group. Furthermore, hypertension, elevated aspartate aminotransferase, procalcitonin, and interleukin 10 were identified as independent risk factors for predicting poor prognosis of SFTS patients. These findings provide valuable insights into the prognostic significance of laboratory markers and highlight the importance of early identification of high-risk SFTS patients.
严重发热伴血小板减少综合征（SFTS）是一种具有显著死亡率的新发传染病。确定影响患者预后的预后因素对于有效的临床管理至关重要。在这项研究中，我们评估了 93 例 SFTS 患者的实验室标志物的动态变化及其与结局的关系。我们发现，年龄和高血压与 SFTS 患者的不良结局显著相关。死亡组的血小板计数较低，肝肾功能标志物、凝血谱、炎症标志物和细胞因子水平较存活组升高。动态分析显示，这些标志物在存活组中逐渐恢复正常，而在死亡组中仍持续异常。此外，高血压、天门冬氨酸氨基转移酶升高、降钙素原和白细胞介素 10 被确定为预测 SFTS 患者预后不良的独立危险因素。这些发现提供了实验室标志物预后意义的有价值的见解，并强调了早期识别高危 SFTS 患者的重要性。
