Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan.
Mod Rheumatol Case Rep. 2023 Dec 29;8(1):159-162. doi: 10.1093/mrcr/rxad059.
We report a 60-year-old male with eosinophilic granulomatosis with polyangiitis (EGPA) complicated with atopic dermatitis (AD). The patient was initially treated with prednisolone, cyclosporine A, and mepolizumab (MEPO). Due to worsening skin symptoms after prednisolone tapering, dupilumab (DUP) was added as an adjunctive therapy for AD confirmed by skin biopsy. The combination therapy of MEPO and DUP resulted in rapid improvement of skin symptoms, suggesting it may be an effective therapeutic option for patients with EGPA and AD. This case report emphasises the importance of a multidisciplinary approach in treating complex diseases such as EGPA and AD.
我们报告了一例 60 岁男性，患有嗜酸性肉芽肿伴多血管炎（EGPA）合并特应性皮炎（AD）。该患者最初接受泼尼松龙、环孢素 A 和美泊利珠单抗（MEPO）治疗。由于泼尼松龙减量后皮肤症状恶化，皮肤活检证实 AD 后加用度普利尤单抗（DUP）作为辅助治疗。MEPO 和 DUP 的联合治疗导致皮肤症状迅速改善，表明其可能是 EGPA 和 AD 患者的有效治疗选择。本病例报告强调了多学科方法在治疗 EGPA 和 AD 等复杂疾病中的重要性。
