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[亚氯酸钠致漂白剂中毒。毒理学与临床病程]

[Bleaching agent poisoning with sodium chlorite. The toxicology and clinical course].

作者信息

Exner-Freisfeld H, Kronenberger H, Meier-Sydow J, Nerger K H

出版信息

Dtsch Med Wochenschr. 1986 Dec 12;111(50):1927-30. doi: 10.1055/s-2008-1068737.

DOI:10.1055/s-2008-1068737
PMID:3780469
Abstract

A woman gardener of 49 years of age suffered an inhalational intoxication from chlorine dioxide while bleaching dried flowers. Preparation of the bleaching solutions was associated with a sharp pungent smell, coughing, pharyngeal irritation and headache. Seven hours later increasing cough and dyspnoea led to hospitalisation. Clinical findings were tachypnoea, tachycardia, and rales of auscultation; clinical chemistry revealed marked leucocytosis. Chest X-ray did not yield any abnormal findings. Initially the vital capacity and forced expiratory volume in 1 s markedly reduced and the resistance correspondingly enhanced. Blood gas analysis showed hypoxaemia despite alveolar hyperventilation. Administration of corticosteroids resulted in significant alleviation of complaints and in improved lung function with stabilisation in a highly normal range, as confirmed by follow-up examination two years later. The chlorine dioxide intoxication had been due to pH level reduction resulting from an incorrect proportioning and handling of the individual bleaching agent components when preparing the solution.

摘要

一名49岁的女园艺工人在漂白干花时吸入二氧化氯中毒。配制漂白溶液时伴有刺鼻气味、咳嗽、咽部刺激和头痛。7小时后,咳嗽加剧和呼吸困难导致其住院治疗。临床检查发现呼吸急促、心动过速及听诊有啰音;临床化学检查显示白细胞显著增多。胸部X线检查未发现任何异常。最初,肺活量和第1秒用力呼气量明显降低,气道阻力相应增加。血气分析显示,尽管存在肺泡过度通气,但仍有低氧血症。给予皮质类固醇后,症状明显缓解,肺功能改善并稳定在高度正常范围内,两年后的随访检查证实了这一点。二氧化氯中毒是由于配制溶液时个别漂白剂成分比例不当和处理不当导致pH值降低所致。

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