Epidemiology and Cancer Statistics Group, Department of Health Sciences, Seebohm Rowntree Building, University of York, York, YO10 5DD, United Kingdom.
Queens Centre for Oncology and Haematology, Castle Hill Hospital, Cottingham, HU16 5JQ, United Kingdom.
Eur J Oncol Nurs. 2023 Dec;67:102421. doi: 10.1016/j.ejon.2023.102421. Epub 2023 Sep 17.
Improvements in chronic myeloid leukaemia treatment mean it is now relevant to examine the experiences of living with this cancer over a lifetime. This qualitative study aimed to investigate the impact of chronic myeloid leukaemia, from patient and healthcare practitioner perspectives.
The research was set within the UK's Haematological Malignancy Research Network; a population-based cohort of patients newly diagnosed with blood cancer, treated at one of fourteen hospitals. Purposive sampling led to interviews with seventeen patients and thirteen health care practitioners. Data were analysed using thematic analysis.
Two analytical themes, "Significant impact of disease and treatment" and "Mediators of the impact of disease and treatment", and six sub-themes, were derived from patient interviews and supported with data from practitioners. Chronic myeloid leukaemia was described by patients as having significant widespread impact, which could be mediated by their knowledge, social support, and the quality of healthcare systems. Practitioners reflected patient accounts, but could underestimate the impact of this cancer. They generally viewed chronic myeloid leukaemia as less complex, severe and impactful than acute blood cancers; a message that reassured patients at diagnosis, but could later unintentionally contribute to difficulties discussing side effects and struggles to cope.
Chronic myeloid leukaemia may significantly impact individuals, particularly as it is experienced over the lifetime. Greater understanding and discussion of the breadth and extent to which patients are affected, including potential mediators, could enhance clinical care.
慢性髓性白血病治疗的改善意味着现在有必要从患者和医疗保健从业者的角度来研究终身患有这种癌症的经历。本定性研究旨在调查慢性髓性白血病的影响。
研究是在英国血液恶性肿瘤研究网络内进行的；这是一个基于人群的新诊断为血液癌的患者队列，在十四家医院之一接受治疗。通过目的性抽样，对十七名患者和十三名医疗保健从业者进行了访谈。使用主题分析对数据进行分析。
从患者访谈中得出了两个分析主题，“疾病和治疗的重大影响”和“疾病和治疗影响的中介因素”，以及六个子主题，这些主题得到了从业者数据的支持。慢性髓性白血病被患者描述为具有广泛的重大影响，这种影响可以通过他们的知识、社会支持和医疗保健系统的质量来调节。从业者反映了患者的描述，但可能低估了这种癌症的影响。他们普遍认为慢性髓性白血病不像急性血液癌那样复杂、严重和具有影响力；这一信息在诊断时让患者感到安心，但后来可能会无意中导致在讨论副作用和应对困难时出现困难。
慢性髓性白血病可能会对个人产生重大影响，尤其是随着时间的推移而产生影响。更深入地了解和讨论患者受到影响的广度和程度，包括潜在的调节因素，可能会改善临床护理。
