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老年髋部手术后转入 ICU 的计划风险评估和临床预测模型。

Risk assessment and clinical prediction model of planned transfer to the ICU after hip arthroplasty in elderly individuals.

机构信息

Meizhou People's Hospital, Meizhou, China.

出版信息

BMC Surg. 2023 Oct 7;23(1):305. doi: 10.1186/s12893-023-02204-2.

Abstract

BACKGROUND

With the development of hip arthroplasty technology and rapid rehabilitation theory, the number of hip arthroplasties in elderly individuals is gradually increasing, and their satisfaction with surgery is also gradually improving. However, for elderly individuals, many basic diseases, poor nutritional status, the probability of surgery, anaesthesia and postoperative complications cannot be ignored. How to reduce the incidence of postoperative complications, optimize medical examination for elderly patients, and reasonably allocate medical resources. This study focuses on the construction of a clinical prediction model for planned transfer to the ICU after hip arthroplasty in elderly individuals.

METHODS

We retrospectively analysed 325 elderly patients who underwent hip arthroplasty. The general data and preoperative laboratory test results of the patients were collected. Univariate and multivariate logistic regression analyses were performed to screen independent influencing factors. The backwards LR method was used to establish the prediction model. Then, we assessed and verified the degree of discrimination, calibration and clinical usefulness of the model. Finally, the prediction model was rendered in the form of a nomogram.

RESULTS

Age, blood glucose, direct bilirubin, glutamic-pyruvic transaminase, serum albumin, prothrombin time and haemoglobin were independent influencing factors of planned transfer to the ICU after hip arthroplasty. The area under the curve (AUC) of discrimination and the 500 bootstrap internal validation AUC of this prediction model was 0.793. The calibration curve fluctuated around the ideal curve and had no obvious deviation from the ideal curve. When the prediction probability was 12%-80%, the clinical decision curve was above two extreme lines. The discrimination, calibration and clinical applicability of this prediction model were good. The clinical prediction model was compared with the seven factors in the model for discrimination and clinical use. The discrimination and clinical practicability of this prediction model were superior to those of the internal factors.

CONCLUSION

The prediction model has good clinical prediction ability and clinical practicability. The model is presented in the form of a linear graph, which provides an effective reference for the individual risk assessment of patients.

摘要

背景

随着髋关节置换技术的发展和快速康复理论的普及,老年髋关节置换手术的数量逐渐增加,他们对手术的满意度也逐渐提高。然而,对于老年人来说,许多基础疾病、较差的营养状况、手术、麻醉和术后并发症的概率不容忽视。如何降低术后并发症的发生率,优化老年患者的体检,合理配置医疗资源。本研究旨在构建老年髋关节置换术后计划转入 ICU 的临床预测模型。

方法

回顾性分析了 325 例老年髋关节置换患者。收集患者的一般资料和术前实验室检查结果。采用单因素和多因素逻辑回归分析筛选独立影响因素。采用向后 LR 法建立预测模型。然后,评估和验证模型的区分度、校准度和临床实用性。最后,以列线图的形式呈现预测模型。

结果

年龄、血糖、直接胆红素、谷丙转氨酶、血清白蛋白、凝血酶原时间和血红蛋白是髋关节置换术后计划转入 ICU 的独立影响因素。该预测模型的区分度曲线下面积(AUC)和 500 次 bootstrap 内部验证 AUC 为 0.793。校准曲线在理想曲线附近波动,与理想曲线无明显偏差。当预测概率为 12%-80%时,临床决策曲线位于两条极值线之上。该预测模型的区分度、校准度和临床适用性均较好。将该预测模型与模型内的七个因素进行比较,以评估其在区分度和临床应用方面的性能。该预测模型在区分度和临床实用性方面均优于模型内因素。

结论

该预测模型具有良好的临床预测能力和临床实用性。该模型以线性图的形式呈现,为患者的个体风险评估提供了有效的参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8721/10559453/9a98bc041dc6/12893_2023_2204_Fig1_HTML.jpg

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