Wang Hang, Hou Xiaoxue, Liu Jianfeng, Yang Cuihong
Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China.
Sheng Wu Gong Cheng Xue Bao. 2023 Sep 25;39(9):3670-3680. doi: 10.13345/j.cjb.220811.
() is an oral anaerobic bacterium that has recently been found to colonize on the surface of colorectal cancer cells in humans, and its degree of enrichment is highly negatively correlated with the prognosis of tumor treatment. Numerous studies have shown that is involved in the occurrence and development of colorectal cancer (CRC), and interacts with multiple components in the tumor microenvironment to increase tumor resistance. In recent years, researchers have begun using nanomedicine to inhibit 's proliferation at the tumor site or directly target to treat CRC. This review summarizes the mechanism of in promoting CRC and the latest research progress on -related CRC therapy using different nanomaterials. Finally, the applications perspective of nanomaterials in -promoted CRC therapy was prospected.
（）是一种口腔厌氧菌，最近被发现可在人类结肠直肠癌细胞表面定殖，其富集程度与肿瘤治疗预后呈高度负相关。大量研究表明，（）参与了结肠直肠癌（CRC）的发生和发展，并且（）与肿瘤微环境中的多种成分相互作用以增加肿瘤抗性。近年来，研究人员已开始使用纳米药物在肿瘤部位抑制（）的增殖或直接靶向（）来治疗CRC。本综述总结了（）促进CRC的机制以及使用不同纳米材料进行与（）相关的CRC治疗的最新研究进展。最后，展望了纳米材料在（）促进的CRC治疗中的应用前景。
