School of Pharmacy, Queen's University Belfast, Belfast, Northern Ireland, UK.
Cancer Research, University College Cork, Cork, Ireland.
Expert Rev Mol Med. 2023 Apr 3;25:e15. doi: 10.1017/erm.2023.9.
Breast cancer was the most commonly diagnosed cancer worldwide in 2020. Greater understanding of the factors which promote tumour progression, metastatic development and therapeutic resistance is needed. In recent years, a distinct microbiome has been detected in the breast, a site previously thought to be sterile. Here, we review the clinical and molecular relevance of the oral anaerobic bacterium in breast cancer. is enriched in breast tumour tissue compared with matched healthy tissue and has been shown to promote mammary tumour growth and metastatic progression in mouse models. Current literature suggests that modulates immune escape and inflammation within the tissue microenvironment, two well-defined hallmarks of cancer. Furthermore, the microbiome, and specifically, has been shown to affect patient response to therapy including immune checkpoint inhibitors. These findings highlight areas of future research needed to better understand the influence of in the development and treatment of breast cancer.
2020 年，乳腺癌是全球最常见的癌症。需要更好地了解促进肿瘤进展、转移发展和治疗耐药性的因素。近年来，人们在以前被认为无菌的乳房中发现了一种独特的微生物组。在这里，我们回顾了口腔厌氧菌 在乳腺癌中的临床和分子相关性。与匹配的健康组织相比， 在乳腺癌组织中更为丰富，并已被证明可促进小鼠模型中的乳腺肿瘤生长和转移进展。目前的文献表明， 通过调节组织微环境中的免疫逃逸和炎症， 这是癌症的两个明确特征。此外，微生物组，特别是 ，已被证明会影响患者对包括免疫检查点抑制剂在内的治疗的反应。这些发现强调了未来需要研究的领域，以更好地了解 在乳腺癌发生和治疗中的影响。
