College of Medicine, Tikrit University, Iraq.
Georgian Med News. 2023 Jul-Aug(340-341):81-86.
Benign prostatic hyperplasia (BPH) is a common benign tumour of the prostate that becomes more common as men age. The purpose of this study is to investigate the relationships between serum zinc and testosterone in BPH patients in Iraq. This case-control study entailed gathering 90 subjects which were separated into two groups, group A consisted of 60 patients with benign prostatic hyperplasia, while group B consisted of 30 healthy males. Diagnosis revealed patient's prostate volumes (PV) were equal to or more than 25 millilitres. Both groups had their serum zinc and serum testosterone levels. The study showed that the mean prostate size was elevated significantly in the BPH group (54.0±8.4cc) as compared with the control group (19.66±2.88cc) (P:0.01). There is a significant reduction in the serum testosterone concentration of benign prostatic hyperplasia patients, (4.05±3.1 ng/ml), as compared with control subjects, (11.37±2.87; p≤0.01). There is a significant reduction in the serum zinc concentration of benign prostatic hyperplasia patients, (70.4±9.63 ng/ml), as compared with control subjects, (99.3±10.5; p≤0.01). The higher percentage of benign prostatic hyperplasia is in patients above 66 years, and the lowest is in the age group 45-55 years. Serum testosterone and zinc are significantly lower in benign prostatic hyperplasia patients than in age-matched healthy controls. All benign prostatic hyperplasia patients have larger prostates than normal healthy control participants of the same BMI. All BMI groups of benign prostatic hyperplasia patients had lower serum testosterone and zinc than normal healthy control persons of the same BMI.
良性前列腺增生（BPH）是一种常见的前列腺良性肿瘤，随着男性年龄的增长变得更加常见。本研究旨在探讨伊拉克 BPH 患者血清锌与睾酮之间的关系。这项病例对照研究共纳入 90 例受试者，分为两组，A 组 60 例为良性前列腺增生患者，B 组 30 例为健康男性。诊断发现患者前列腺体积（PV）等于或大于 25 毫升。两组均检测血清锌和血清睾酮水平。研究表明，BPH 组前列腺大小的平均值明显升高（54.0±8.4cc），与对照组（19.66±2.88cc）相比（P：0.01）。与对照组相比，良性前列腺增生患者的血清睾酮浓度显著降低（4.05±3.1ng/ml），（P≤0.01）。与对照组相比，良性前列腺增生患者的血清锌浓度显著降低（70.4±9.63ng/ml），（P≤0.01）。66 岁以上患者良性前列腺增生的比例较高，45-55 岁年龄组最低。与年龄匹配的健康对照组相比，良性前列腺增生患者的血清睾酮和锌均显著降低。所有良性前列腺增生患者的前列腺均大于相同 BMI 的正常健康对照组参与者。所有 BMI 组的良性前列腺增生患者的血清睾酮和锌均低于相同 BMI 的正常健康对照者。
