Department of Otolaryngology - Head and Neck Surgery, New York Presbyterian Hospital- Columbia University Irving Medical Center, New York, NY, USA.
Department of Management and Organizations, Kellogg School of Management- Northwestern University, Evanston, IL, USA.
Rhinology. 2024 Feb 1;62(1):71-81. doi: 10.4193/Rhin23.172.
Patient-reported outcome measures (PROMs) are questionnaires designed to assess a patient's perception of their medical condition. The 22-item Sino-Nasal Outcomes Test (SNOT-22), the Rhinosinusitis Disability Index (RSDI) and the mini-Rhinoconjunctivitis Quality of Life Questionnaire (MiniRQLQ) are validated PROMs commonly used to assess rhinologic conditions. The objective of this study is to determine if responses on these PROMs may be influenced by priming respondents with positive or negative health-related questionnaires.
Nine hundred patients were prospectively randomized to one of nine groups. Groups A, D and G were positively primed prior to completing the SNOT-22, the RSDI and MiniRQLQ, respectively. Groups B, E, and H were negatively primed. Groups C, F, and I served as control groups, completing the PROMs without priming. Priming was performed by administering a survey designed to make patients think about their health-related quality of life in a positive or negative way.
Patients who were primed negatively had statistically significantly worse scores on the SNOT-22, RSDI and MiniRQLQ when compared to patients who were primed positively. When compared to the control group, patients who were primed negatively had statistically worse scores on the SNOT-22 and RSDI. There was no significant difference in scores between the positive priming and the control groups for any PROM.
Priming subjects regarding their health-related quality of life impacts their responses on rhinologic PROMs. Further study is required to understand the clinical and research implications of this novel finding and to clarify the optimal manner for administering and interpreting PROMs.
患者报告的结局测量（PROMs）是旨在评估患者对其医疗状况感知的问卷。22 项鼻-鼻窦炎结局测试（SNOT-22）、鼻-鼻窦炎患者生存质量量表（RSDI）和迷你鼻结膜炎生存质量问卷（MiniRQLQ）是评估鼻科疾病的常用验证性 PROMs。本研究的目的是确定这些 PROM 的回答是否可能受到用正面或负面的健康相关问卷对受访者进行启动的影响。
900 名患者前瞻性随机分为九组。组 A、D 和 G 在完成 SNOT-22、RSDI 和 MiniRQLQ 之前分别接受正面启动，组 B、E 和 H 接受负面启动。组 C、F 和 I 作为对照组，在没有启动的情况下完成 PROMs。启动是通过进行一项旨在使患者以积极或消极的方式思考他们的健康相关生活质量的调查来完成的。
与接受正面启动的患者相比，接受负面启动的患者在 SNOT-22、RSDI 和 MiniRQLQ 上的评分有统计学上的显著恶化。与对照组相比，接受负面启动的患者在 SNOT-22 和 RSDI 上的评分有统计学上的恶化。在任何 PROM 上，正面启动和对照组之间的评分均无显著差异。
启动患者的健康相关生活质量会影响他们对鼻科 PROM 的反应。需要进一步研究以了解这一新颖发现的临床和研究意义，并阐明管理和解释 PROMs 的最佳方式。
