持续性阴道毛滴虫感染和假囊形式。
Persistent Trichomonas vaginalis infections and the pseudocyst form.
机构信息
Center for Genomics and Systems Biology, Department of Biology, 12 Waverly Place, New York City, NY 10003, USA.
Department of Biomedical and Diagnostic Sciences, University of Tennessee, Knoxville, TN 37996, USA.
出版信息
Trends Parasitol. 2023 Dec;39(12):1023-1031. doi: 10.1016/j.pt.2023.09.009. Epub 2023 Oct 6.
Recent studies have proposed that Trichomonas vaginalis, the causative agent of trichomoniasis [the most common nonviral sexually transmitted infection (STI) in humans] can establish persistent infections in the vagina. T. vaginalis infections are often asymptomatic but can have adverse consequences such as increased risk of HIV-1 infection and cervical cancer. Despite this, it remains an understudied infection. A potential agent of persistent infections is the 'pseudocyst', a spherical form of T. vaginalis identified by several laboratories and linked to persistence in related species such as the avian parasite Trichomonas gallinae and cattle parasite Tritrichomonas foetus. Additional robust and reproducible research on pseudocysts and persistent T. vaginalis infections is required, which may ultimately shed light on how to better diagnose and treat trichomoniasis.
最近的研究表明，阴道毛滴虫是滴虫病（人类最常见的非病毒性性传播感染）的病原体，它可以在阴道中建立持续性感染。阴道毛滴虫感染通常无症状，但可能会产生不良后果，如增加 HIV-1 感染和宫颈癌的风险。尽管如此，它仍然是一种研究不足的感染。持续性感染的一个潜在因素是“假囊”，这是阴道毛滴虫的一种球形形式，已被多个实验室鉴定，并与相关物种（如禽类寄生虫阴道毛滴虫和牛寄生虫三虫毛滴虫）的持续性感染有关。需要对假囊和持续性阴道毛滴虫感染进行更多稳健且可重复的研究，这最终可能有助于阐明如何更好地诊断和治疗滴虫病。
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