多用途滴眼液、凝胶和眼膏的细菌污染。

Bacterial contamination of multi-use tear drops, gels, and ointments.

机构信息

Goztepe Prof. Dr. Süleyman Yalçin City Hospital, Department of Ophthalmology, Istanbul, Turkey.

Goztepe Prof. Dr. Süleyman Yalçin City Hospital, Department of Medical Microbiology, Istanbul, Turkey.

出版信息

Cont Lens Anterior Eye. 2023 Dec;46(6):102064. doi: 10.1016/j.clae.2023.102064. Epub 2023 Oct 6.

DOI:10.1016/j.clae.2023.102064

PMID:37806847

Abstract

PURPOSE

This study aimed to investigate the bacterial contamination of multi-use tear drops, gels, and ointments that patients use at home.

METHOD

A total of 271 multi-use containers used by 168 patients were examined. Conjunctival culture samples were obtained from patients who used tear drops, gels, and ointments that were found to be contaminated.

RESULTS

Bacterial contamination was detected in 33 (12.2 %) out of the 271 containers. The contamination rate was 7.9 % in tear drops, 11.7 % in gels, and 32 % in ointments. A statistically significant difference was found between the drops, gels, and ointment groups (P = 0.04). Bacterial contamination was detected in 25 (18.9 %) out of 132 collapsible tubes and 8 (5.8 %) out of 139 plastic bottles (P = 0.01). Important bacteria, including Pseudomonas stutzeri, Pseudomonas aeruginosa, Bacillus licheniformis, Paenibacillus pabuli, Proteus mirabilis, Pantoea agglomerans, Morganella morganii, Serratia marcescens, and Serratia liquefaciens, were detected. Mucorales spp. fungus was seen in a gel. Staphylococcus epidermidis, methicillin-resistant Staphylococcus aureus, and M. morganii were found in the conjunctival microbiota of three patients.

CONCLUSION

The overall contamination rate of ocular lubricants was low (12.2%); however, a significant difference was found between the drops, gels, and ointments. The contamination rate was higher in gels and ointments than that in drops. The contamination rate was found to be increased in the collapsible tube. The use of ocular lubricants is safe; however, patients must be cautious when using multi-use tear drops, gels, and ointments to avoid contamination. Whenever possible, bottles should be preferred instead of collapsible tubes.

摘要

目的

本研究旨在调查患者在家中使用的多用途滴眼液、凝胶和眼膏的细菌污染情况。

方法

共检查了 168 名患者使用的 271 个多用途容器。从使用被污染的滴眼液、凝胶和眼膏的患者中获得结膜培养样本。

结果

在 271 个容器中，有 33 个（12.2%）检测到细菌污染。滴眼液的污染率为 7.9%，凝胶为 11.7%，眼膏为 32%。滴注组、凝胶组和眼膏组之间存在统计学差异（P=0.04）。在 132 个可折叠管中有 25 个（18.9%）和在 139 个塑料瓶中有 8 个（5.8%）检测到细菌污染（P=0.01）。检测到包括恶臭假单胞菌、铜绿假单胞菌、地衣芽孢杆菌、成团泛菌、奇异变形杆菌、聚集肠杆菌、摩氏摩根菌、粘质沙雷菌和液化沙雷菌在内的重要细菌。在凝胶中发现了毛霉科真菌。在 3 名患者的结膜微生物群中发现了表皮葡萄球菌、耐甲氧西林金黄色葡萄球菌和摩氏摩根菌。