Gross Daniel J, Alnajar Ahmed, Villamizar Nestor R, Nguyen Dao M
Division of Thoracic Surgery, The DeWitt Daughtry Department of Surgery, The University of Miami, Miami, Fla.
JTCVS Open. 2023 Jul 6;15:508-519. doi: 10.1016/j.xjon.2023.06.017. eCollection 2023 Sep.
Enhanced recovery after thoracic surgery (ERATS) protocols use a combination of analgesics for pain control and have been associated with decreased opioid requirements. We investigated the impact of continual ERATS refinement on the incidence of opioid-free discharge.
We retrospectively analyzed our prospectively maintained institutional database for elective, opioid-naive robotic thoracoscopic procedures. Demographics, operative outcomes, postoperative opioid dispensed (morphine milligram equivalent), and opioid discharge status were collected. Our primary outcome of interest was factors associated with opioid-free discharge; our secondary objective was to determine the incidence of new persistent opioid users.
In total, 466 patients from our optimized ERATS protocol were included; 309 (66%) were discharged without opioids. However, 34 (11%) of patients discharged without opioids required a prescription postdischarge. Conversely, 7 of 157 patients (11%), never filled their opioid prescriptions given at discharge. Factors associated with opioid-free discharges were nonanatomic resections, mediastinal procedures, minimal pain, and lack of opioid usage on the day of discharge. More importantly, 3.2% of opioid-free discharge patients became new persistent opioid users versus 10.8% of patients filling opioid prescriptions after discharges ( = .0013). Finally, only 2.3% of opioid-naive patients of the entire cohort became chronic opioid users; there was no difference in the incidence of chronic use by opioid discharge status.
Optimized opioid-sparing ERATS protocols are highly effective in reducing opioid prescription on the day of discharge. We observed a very low rate of new persistent or chronic opioid use in our cohort, further highlighting the role ERATS protocols in combating the opioid epidemic.
胸外科手术后加速康复(ERATS)方案采用多种镇痛药联合控制疼痛,且与阿片类药物需求量减少相关。我们研究了持续优化ERATS方案对无阿片类药物出院发生率的影响。
我们回顾性分析了前瞻性维护的机构数据库中择期、未使用过阿片类药物的机器人辅助胸腔镜手术病例。收集患者的人口统计学资料、手术结果、术后阿片类药物用量(吗啡毫克当量)及阿片类药物出院状态。我们感兴趣的主要结局是与无阿片类药物出院相关的因素;次要目的是确定新的持续使用阿片类药物患者的发生率。
总共纳入了466例采用优化ERATS方案的患者;其中309例(66%)出院时未使用阿片类药物。然而,34例(11%)出院时未使用阿片类药物的患者出院后需要开具阿片类药物处方。相反,157例患者中有7例(11%)从未领取出院时开具的阿片类药物处方。与无阿片类药物出院相关的因素包括非解剖性切除、纵隔手术、疼痛轻微以及出院当天未使用阿片类药物。更重要的是,无阿片类药物出院患者中有3.2%成为新的持续使用阿片类药物患者,而出院后领取阿片类药物处方的患者中有10.8%成为新的持续使用阿片类药物患者(P = 0.0013)。最后,整个队列中未使用过阿片类药物的患者仅有2.3%成为慢性阿片类药物使用者;阿片类药物出院状态不同,慢性使用的发生率无差异。
优化的减少阿片类药物使用的ERATS方案在出院当天减少阿片类药物处方方面非常有效。我们观察到队列中新的持续或慢性阿片类药物使用率非常低,进一步凸显了ERATS方案在对抗阿片类药物流行中的作用。