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Dicyclomine- and pirenzepine-sensitive muscarinic receptors mediate inhibition of [3H]serotonin release in different rat brain areas.

作者信息

Marchi M, Paudice P, Bella M, Raiteri M

出版信息

Eur J Pharmacol. 1986 Oct 7;129(3):353-7. doi: 10.1016/0014-2999(86)90446-2.

DOI:10.1016/0014-2999(86)90446-2
PMID:3780848
Abstract

The effects of acetylcholine (ACh) on the release of [3H]5-hydroxytryptamine ([3H]5-HT) were investigated in synaptosomes prepared from rat cerebral cortex, hypothalamus and hippocampus and depolarized with 15 mM KCl under superfusion conditions. ACh inhibited the release of [3H]5-HT in all three brain areas. This effect was not modified by hexamethonium but was antagonized by atropine and by the non-classical antagonists pirenzepine and dicyclomine.

摘要

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