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槟榔对中枢神经系统和肝脏的急性毒性作用:一例报告

Acute toxic effects of areca nut on central nervous system and liver: A case report.

作者信息

Mahdavi Mortazavi Seyede Maryam, Ataollahi Maryam, Mashhadiagha Amirali, Moosavi Seyed Ali, Moshfeghinia Reze, Soheili Marzieh

机构信息

Department of Pediatrics, School of Medicine, Namazi Teaching Hospital Shiraz University of Medical Sciences Shiraz Iran.

Department of Pediatrics, School of Medicine, Namazi Teaching Hospital, Abu Ali Sina Center for Medicine & Organ Transplant Shiraz University of Medical Sciences Shiraz Iran.

出版信息

Clin Case Rep. 2023 Oct 4;11(10):e7976. doi: 10.1002/ccr3.7976. eCollection 2023 Oct.

DOI:10.1002/ccr3.7976
PMID:37808574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10551103/
Abstract

Areca nut (AN) is an addictive substance widely used in different world regions. There are several side effects associated with the use of AN, which have already been reported. However, the reports on hepatotoxicity of AN are sporadic and non-conclusive. In the present case report, we investigated the hepatotoxicity of AN in a four-year-old Iranian girl who was transferred to our medical center with abdominal pain, vomiting, diarrhea, fever, and other symptoms such as hematuria, decreased mental status, multiple seizure episodes. After a comprehensive evaluation, it was concluded that these signs and symptoms were all attributed to AN consumption, which was given by her mother to control diarrhea. Eventually, the patient medical conditions were managed successfully, and she survived by intense medical care. In conclusion, we suggest AN should be considered a potential hepatotoxic agent.

摘要

槟榔是一种在世界不同地区广泛使用的成瘾性物质。使用槟榔会产生多种副作用,这些副作用已有报道。然而,关于槟榔肝毒性的报道零星且无定论。在本病例报告中,我们调查了一名四岁伊朗女孩的槟榔肝毒性,该女孩因腹痛、呕吐、腹泻、发热以及血尿、精神状态下降、多次癫痫发作等其他症状被转诊至我们的医疗中心。经过全面评估,得出结论这些体征和症状均归因于食用槟榔,槟榔是其母亲给她用来控制腹泻的。最终,患者的病情得到成功处理,通过强化医疗护理得以存活。总之,我们建议应将槟榔视为一种潜在的肝毒性物质。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ead4/10551103/6ce61c39a1b5/CCR3-11-e7976-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ead4/10551103/6ce61c39a1b5/CCR3-11-e7976-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ead4/10551103/6ce61c39a1b5/CCR3-11-e7976-g001.jpg

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引用本文的文献

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本文引用的文献

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Areca nut trade, globalisation and its health impact: perspectives from India and South-east Asia.槟榔贸易、全球化及其对健康的影响:来自印度和东南亚的观点。
Perspect Public Health. 2019 Jan;139(1):44-48. doi: 10.1177/1757913918785398. Epub 2018 Jun 29.
2
Areca catechu (palm tree) nut chewing and seizures: An observational study.槟榔咀嚼与癫痫发作:一项观察性研究。
Epilepsy Behav. 2017 Sep;74:76-80. doi: 10.1016/j.yebeh.2017.06.028. Epub 2017 Jul 18.
3
Hepatic Shock Differential Diagnosis and Risk Factors: A Review Article.
肝性休克的鉴别诊断与危险因素:一篇综述文章
Hepat Mon. 2015 Oct 10;15(10):e27063. doi: 10.5812/hepatmon.27063. eCollection 2015 Oct.
4
A review of the systemic adverse effects of areca nut or betel nut.槟榔的全身不良反应综述。
Indian J Med Paediatr Oncol. 2014 Jan;35(1):3-9. doi: 10.4103/0971-5851.133702.
5
Tobacco and areca nut chewing--reproductive impairments: an overview.烟草和槟榔咀嚼——生殖损伤:概述。
Reprod Toxicol. 2013 Apr;36:12-7. doi: 10.1016/j.reprotox.2012.11.007. Epub 2012 Dec 1.
6
Areca-nut chewing habit is a significant risk factor for metabolic syndrome: a systematic review.咀嚼槟榔习惯是代谢综合征的一个重要危险因素:系统评价。
J Nutr Health Aging. 2012 May;16(5):445-8. doi: 10.1007/s12603-011-0353-5.
7
Prevalence and determinants of biochemical dysfunction of the liver in Atayal Aboriginal community of Taiwan: is betel nut chewing a risk factor?台湾泰雅原住民社区肝脏生化功能障碍的患病率及决定因素:嚼槟榔是一个风险因素吗?
BMC Gastroenterol. 2008 Apr 27;8:13. doi: 10.1186/1471-230X-8-13.
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Arecoline-induced growth arrest and p21WAF1 expression are dependent on p53 in rat hepatocytes.槟榔碱诱导的大鼠肝细胞生长停滞和p21WAF1表达依赖于p53。
Toxicology. 2008 Jan 14;243(1-2):1-10. doi: 10.1016/j.tox.2007.09.003. Epub 2007 Sep 8.
9
Betel-quid and areca-nut chewing and some areca-nut derived nitrosamines.嚼食槟榔和槟榔果以及一些槟榔衍生的亚硝胺。
IARC Monogr Eval Carcinog Risks Hum. 2004;85:1-334.
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Epidemiology of betel quid usage.嚼食槟榔的流行病学。
Ann Acad Med Singap. 2004 Jul;33(4 Suppl):31-6.