Wolińska-Witort E, Przekop F, Mateusiak K, Domański E
Exp Clin Endocrinol. 1986 Aug;87(3):265-76. doi: 10.1055/s-0029-1210555.
The effect of repeated and prolonged stress-stimuli applied during 3 days on the plasma prolactin concentration in sheep, in anoestrous, prooestrous and pregnant animals were studied. The following results were obtained: Repeated and prolonged weak electric stimuli applied in the form of footshocks in sheep during 3 days elicited a rise of mesor plasma concentration. The magnitude and the onset of this rise was not associated and dependent on the physiological state of animals. The mesor values of plasma prolactin concentration in all groups of animals except prooestrous ewes on the day following stimulation returned to their prestressing levels. Repeated and prolonged stimuli disturbed circadian rhythm of prolactin secretion existing only in prooestrous ewes, i.e. they caused its disappearance on the days during stimulation and its reappearance on the day following stimulation but at an accelerated and inverse time of the day to that found before stimulation. The induced rise of plasma prolactin concentration in anoestrous and pregnant ewes on the days during electric stimulation showed, according to Cosinor analysis, all features characteristic for acrophase of the circadian rhythm. This phenomenon may be considered as induced acrophase in stress condition.
研究了连续3天施加反复且长时间的应激刺激对处于乏情期、发情前期和妊娠期的绵羊血浆催乳素浓度的影响。得到以下结果：连续3天以足部电击的形式对绵羊施加反复且长时间的弱电刺激，引发了血浆中值浓度升高。这种升高的幅度和起始时间与动物的生理状态无关且不依赖于动物的生理状态。除发情前期母羊外，所有组动物在刺激后一天血浆催乳素浓度的中值恢复到应激前水平。反复且长时间的刺激扰乱了仅存在于发情前期母羊中的催乳素分泌的昼夜节律，即刺激期间催乳素分泌的昼夜节律消失，刺激后一天重新出现，但出现时间提前且与刺激前相反。根据余弦分析，在电击刺激期间，乏情期和妊娠期母羊血浆催乳素浓度的诱导升高表现出昼夜节律峰相位的所有特征。这种现象可被视为应激条件下的诱导峰相位。
