Flowers Lauren, Witte Luke, Zurowski Susan M
Department of Dermatology, University of Missouri School of Medicine, Columbia, USA.
Department of Dermatology, University of Missouri, Columbia, USA.
Cureus. 2023 Sep 5;15(9):e44738. doi: 10.7759/cureus.44738. eCollection 2023 Sep.
() is an increasingly prevalent and treatment-resistant opportunistic fungus. The pathogen is known to cause a variety of clinical manifestations ranging from localized cutaneous disease to disseminated systemic infection. Herein we present an otherwise healthy 41-year-old male with biopsy-proven cutaneous infection. The patient experienced drastic clinical improvement on two months of a combination of oral itraconazole and oral minocycline. exhibits resistance to many antifungal agents, thus, single-agent antifungal therapy has a high failure rate and often results in the need for surgical excision or debridement. Recent accounts suggest that minocycline in combination with azole antifungals has a synergistic effect in treating . This case highlights the excellent response to combination oral therapies with minocycline and itraconazole. Prompt and efficacious treatment reduces the risk of destructive or disseminated disease and may avoid the need for surgical intervention.
（）是一种日益普遍且耐药的机会性真菌。已知该病原体可引起从局部皮肤疾病到播散性全身感染的多种临床表现。在此，我们报告一名41岁的健康男性，经活检证实患有皮肤感染。该患者在口服伊曲康唑和口服米诺环素联合治疗两个月后临床症状显著改善。（）对许多抗真菌药物耐药，因此，单药抗真菌治疗失败率很高，常常需要手术切除或清创。最近的报道表明，米诺环素与唑类抗真菌药联合使用在治疗（）方面具有协同作用。本病例突出了米诺环素和伊曲康唑联合口服治疗的良好效果。及时有效的治疗可降低破坏性或播散性疾病的风险，并可能避免手术干预的需要。
