Kumari Riya, Muneshwar Komal N, Pathade Aniket G, Yelne Seema
Community Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Research and Development, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Cureus. 2023 Sep 5;15(9):e44752. doi: 10.7759/cureus.44752. eCollection 2023 Sep.
Triptorelin, a synthetic gonadotropin-releasing hormone (GnRH) agonist, has garnered increasing attention for its profound effects on endocrine profiles across diverse populations. This review article explores triptorelin's impact on women's health by examining its effects on healthy individuals, those with polycystic ovary syndrome (PCOS), and those experiencing hypothalamic amenorrhea (HA). The mechanism of triptorelin involves a transient surge in gonadotropin release, followed by receptor desensitization, leading to downregulation of the hypothalamus-pituitary-gonadal (HPG) axis. In healthy women, triptorelin's controlled modulation of the HPG axis is a foundation for assisted reproduction techniques. In PCOS, it offers promise in restoring ovulatory function and mitigating hyperandrogenism. For HA individuals, triptorelin's potential to restore proper GnRH pulsatility emerges as a therapeutic avenue. This review emphasizes the importance of personalized approaches based on specific health conditions, highlighting triptorelin's versatility and potential applications beyond its current scope. As research progresses, triptorelin's role in endocrine management is poised to reshape women's health by optimizing hormonal equilibrium and overall well-being.
曲普瑞林是一种合成的促性腺激素释放激素（GnRH）激动剂，因其对不同人群内分泌状况的深远影响而受到越来越多的关注。这篇综述文章通过研究曲普瑞林对健康个体、多囊卵巢综合征（PCOS）患者以及下丘脑性闭经（HA）患者的影响，探讨了其对女性健康的作用。曲普瑞林的作用机制包括促性腺激素释放的短暂激增，随后是受体脱敏，导致下丘脑 - 垂体 - 性腺（HPG）轴下调。在健康女性中，曲普瑞林对HPG轴的可控调节是辅助生殖技术的基础。在PCOS中，它有望恢复排卵功能并减轻高雄激素血症。对于HA患者，曲普瑞林恢复适当GnRH脉冲性的潜力成为一种治疗途径。本综述强调了基于特定健康状况的个性化方法的重要性，突出了曲普瑞林的多功能性及其超出当前范围的潜在应用。随着研究的进展，曲普瑞林在内分泌管理中的作用有望通过优化激素平衡和整体健康状况来重塑女性健康。
