Marti H P, Murrell K D
Exp Parasitol. 1986 Dec;62(3):370-5. doi: 10.1016/0014-4894(86)90044-5.
The development of antifecundity and antinewborn larvae immunity in swine infected with Trichinella spiralis was investigated. In primary infections, adult female worm fecundity dropped sharply after 3 weeks, although adults could be recovered from the small intestine for at least 7 weeks after infection. In challenge infections of pigs infected previously, adult female worm fecundity was depressed up to 51% and the adults were expelled within 3 weeks. Since immune pigs are almost completely resistant to the secondary establishment of muscle larvae, this suggested the existence of immune effector mechanisms also acting on the newborn larvae. This was supported by observations, using an indirect fluorescent antibody assay, that pig antibody bound to the surface of the newborn larvae. Passive transfer of immune pig serum resulted in a large reduction in muscle larvae burden in both infected pig and rat recipients. Adult female worm fecundity in such immune serum recipients was reduced only by 20% and worm survival in the intestine was unaffected. These results indicate that immunity to the newborn larvae, in addition to antifecundity effects, are responsible for the high levels of acquired resistance to T. spiralis in swine.
研究了感染旋毛虫的猪的抗生育力和抗新生幼虫免疫力的发展情况。在初次感染中，成年雌虫的生育力在3周后急剧下降，尽管感染后至少7周仍可从小肠中回收成虫。在先前感染过的猪的再次感染中，成年雌虫的生育力降低了51%，成虫在3周内被排出。由于免疫猪几乎完全抵抗肌肉幼虫的二次寄生，这表明存在也作用于新生幼虫的免疫效应机制。使用间接荧光抗体试验的观察结果支持了这一点，即猪抗体与新生幼虫的表面结合。免疫猪血清的被动转移导致感染猪和大鼠受体中的肌肉幼虫负荷大幅降低。在这种免疫血清受体中，成年雌虫的生育力仅降低了20%，肠道中蠕虫的存活未受影响。这些结果表明，除了抗生育力作用外，对新生幼虫的免疫力是猪对旋毛虫获得性高抗性的原因。
