癌症相关成纤维细胞在膀胱癌进展中的作用。
The role of cancer-associated fibroblasts in bladder cancer progression.
作者信息
Huang Long, Xie Qun, Deng Jian, Wei Wen-Fei
机构信息
Department of Urology, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, Guangdong, China.
Department of Gynecology, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, Guangdong, China.
出版信息
Heliyon. 2023 Sep 4;9(9):e19802. doi: 10.1016/j.heliyon.2023.e19802. eCollection 2023 Sep.
Cancer-associated fibroblasts (CAFs) are key stromal cells in the tumor microenvironment (TME) that critically contribute to cancer initiation and progression. In bladder cancer (BCa), there is emerging evidence that BCa CAFs are actively involved in cancer cell proliferation, invasion, metastasis, and chemotherapy resistance. This review outlines the present knowledge of BCa CAFs, with a particular emphasis on their origin and function in BCa progression, and provides further insights into their clinical application.
癌症相关成纤维细胞（CAFs）是肿瘤微环境（TME）中的关键基质细胞，对癌症的发生和发展起着至关重要的作用。在膀胱癌（BCa）中，越来越多的证据表明，BCa CAFs积极参与癌细胞的增殖、侵袭、转移和化疗耐药。这篇综述概述了目前关于BCa CAFs的知识，特别强调了它们在BCa进展中的起源和功能，并对其临床应用提供了进一步的见解。
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