癌症中的激活成纤维细胞：观点和挑战。
Activated fibroblasts in cancer: Perspectives and challenges.
机构信息
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA; Lustgarten Foundation Pancreatic Cancer Research Laboratory, Cold Spring Harbor, NY, USA.
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA; Lustgarten Foundation Pancreatic Cancer Research Laboratory, Cold Spring Harbor, NY, USA.
出版信息
Cancer Cell. 2023 Mar 13;41(3):434-449. doi: 10.1016/j.ccell.2023.02.015.
Abstract
Activated fibroblasts in tumors, or cancer-associated fibroblasts (CAFs), have become a popular research area over the past decade. As important players in many aspects of tumor biology, with functions ranging from collagen deposition to immunosuppression, CAFs have been the target of clinical and pre-clinical studies that have revealed their potential pro- and anti-tumorigenic dichotomy. In this review, we describe the important role of CAFs in the tumor microenvironment and the technological advances that made these discoveries possible, and we detail the models that are currently available for CAF investigation. Additionally, we present evidence to support the value of encompassing CAF investigation as a future therapeutic avenue alongside immune and cancer cells while highlighting the challenges that must be addressed for successful clinical translation of new findings.
摘要
在过去的十年中，肿瘤中活化的成纤维细胞或癌症相关成纤维细胞（CAFs）已成为一个热门研究领域。作为肿瘤生物学许多方面的重要参与者，CAFs 的功能从胶原蛋白沉积到免疫抑制不等，已成为临床前和临床研究的目标，这些研究揭示了它们潜在的促肿瘤和抗肿瘤二分法。在这篇综述中，我们描述了 CAFs 在肿瘤微环境中的重要作用，以及促成这些发现的技术进步，并详细介绍了目前可用于 CAF 研究的模型。此外，我们还提供了证据，支持将 CAF 研究作为免疫和癌细胞治疗途径的未来方向，同时强调了为成功将新发现转化为临床应用而必须解决的挑战。
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