Kanabaj Krzysztof, Jenerowicz Dorota, Jankowska Lucyna, Żaba Zbigniew
Department of Dermatology, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-356, Poznan, Poland.
Department of Emergency Medicine, Poznan University of Medical Sciences, ul. Rokietnicka 7, 60-806, Poznan, Poland.
Heliyon. 2023 Sep 9;9(9):e20021. doi: 10.1016/j.heliyon.2023.e20021. eCollection 2023 Sep.
Drug reaction with eosinophilia and systemic symptoms (DRESS syndrome) or drug-induced hypersensitivity syndrome (DIHS) is a severe skin reaction associated with general symptoms and mortality reaching up to 10% of cases. DRESS/DIHS is one of the few dermatological emergencies which need to be taken into consideration when dealing with a patient with acute exanthema and systemic symptoms like: fever, lymphadenopathy, muscle pain, hepatosplenomegaly, abnormal blood count results and systemic inflammation. The aim of this article is to summarize the literature finding regarding this dermatological emergency and present the case of a 42-year-old male suffering from DRESS syndrome as a consequence of sulfasalazine intake due to an inflammatory bowel disease, who was effectively treated with oral prednisolone and immediate drug withdrawal.
药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS综合征）或药物性超敏反应综合征（DIHS）是一种严重的皮肤反应，伴有全身症状，死亡率高达10%。DRESS/DIHS是少数几种在处理急性皮疹和全身症状（如发热、淋巴结病、肌肉疼痛、肝脾肿大、血常规结果异常和全身炎症）患者时需要考虑的皮肤科急症之一。本文的目的是总结关于这种皮肤科急症的文献发现，并介绍一例42岁男性因炎症性肠病服用柳氮磺胺吡啶而患上DRESS综合征的病例，该患者通过口服泼尼松龙和立即停药得到了有效治疗。
