Shahar Sivan, Lynch Sean, Dornbush Rhea, Klepacz Lidia, Smiley Abbas, Ferrando Stephen J
Department of Psychiatry and Behavioral Sciences, New York Medical College, Valhalla, NY, USA.
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, New York City, NY, USA.
Neuropsychiatr Dis Treat. 2023 Oct 3;19:2069-2079. doi: 10.2147/NDT.S427957. eCollection 2023.
Approximately one-third of COVID-19 survivors will experience persistent symptoms, which may include neurological and psychiatric disturbances. Previous research has suggested that up to 45% of people develop clinically significant depressive symptoms post-COVID. This study sought to determine frequency, symptom profile, and clinical correlates of depression post-COVID.
Seventy-five participants who had recovered from COVID-19 underwent neurocognitive, psychiatric, medical, and cognitive testing/screening. The primary measures of interest in this report included the Patient Health Questionnaire (PHQ-9), a 9-item depression-screening tool, and the Endicott Quality of Life Enjoyment and Satisfaction Questionnaire.
One-third of study participants screened as positive on the PHQ-9 for clinically significant depression, with the most commonly reported symptom being fatigue, followed by sleep disturbance and poor concentration. Also reported were decreased satisfaction in employment, sexual life, and mood. Depressed patients described greater illness severity during COVID-19 infection and subjective cognitive impairment, which was not found on neurocognitive testing. The only significant predictor of depression was COVID-19 illness severity.
A significant portion of participants was a clinical population with specific post-COVID complaints and was predominately comprised of white females. Formal psychiatric evaluation was not performed.
Many individuals may experience depression after COVID-19 infection, with symptoms appearing to be predominately somatic in nature and correspond with COVID-19 illness severity.
约三分之一的新冠病毒病康复者会出现持续症状，其中可能包括神经和精神方面的紊乱。此前的研究表明，高达45%的人在感染新冠病毒病后会出现具有临床意义的抑郁症状。本研究旨在确定感染新冠病毒病后抑郁的发生率、症状特征及临床相关因素。
75名新冠病毒病康复者接受了神经认知、精神、医学及认知测试/筛查。本报告中主要关注的指标包括患者健康问卷（PHQ-9，一种9项抑郁筛查工具）和恩迪科特生活质量享受与满意度问卷。
三分之一的研究参与者在PHQ-9上筛查出具有临床意义的抑郁阳性，最常报告的症状是疲劳，其次是睡眠障碍和注意力不集中。还报告了就业、性生活和情绪方面的满意度下降。抑郁患者描述了新冠病毒病感染期间更严重的疾病程度和主观认知障碍，但在神经认知测试中未发现。抑郁的唯一显著预测因素是新冠病毒病的疾病严重程度。
很大一部分参与者是有特定新冠病毒病后症状的临床人群，且主要由白人女性组成。未进行正式的精神评估。
许多人在感染新冠病毒病后可能会出现抑郁，症状似乎主要为躯体性，且与新冠病毒病的疾病严重程度相关。
