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肥厚型心肌病患者心律失常发生中离子通道损伤的机制

Mechanism of Ion Channel Impairment in the Occurrence of Arrhythmia in Patients with Hypertrophic Cardiomyopathy.

作者信息

Zhang Ke, Wang Shengwei, Li Xiaoyan, Cui Hao, Lai Yongqiang

机构信息

From the Department of Cardiovascular Surgery.

The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China.

出版信息

Cardiol Rev. 2025;33(3):260-264. doi: 10.1097/CRD.0000000000000612. Epub 2023 Oct 9.

DOI:10.1097/CRD.0000000000000612
PMID:37812010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11969372/
Abstract

Sudden cardiac death is the most unpredictable and devastating consequence of hypertrophic cardiomyopathy, most often caused by persistent ventricular tachycardia or ventricular fibrillation. Although myocardial hypertrophy, fibrosis, and microvascular disorders are the main mechanisms of persistent reentrant ventricular arrhythmias in patients with advanced hypertrophic cardiomyopathy, the cardiomyocyte mechanism based on ion channel abnormalities may play an important role in the early stages of the disease.

摘要

心源性猝死是肥厚型心肌病最不可预测且最具破坏性的后果，通常由持续性室性心动过速或心室颤动引起。尽管心肌肥厚、纤维化和微血管病变是晚期肥厚型心肌病患者持续性折返性室性心律失常的主要机制，但基于离子通道异常的心肌细胞机制可能在疾病早期起重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52ad/11969372/7ef1722b7d45/crd-33-260-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52ad/11969372/7ef1722b7d45/crd-33-260-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52ad/11969372/7ef1722b7d45/crd-33-260-g001.jpg

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本文引用的文献

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Disease modeling of a mutation in α-actinin 2 guides clinical therapy in hypertrophic cardiomyopathy.α-辅肌动蛋白2突变的疾病建模指导肥厚型心肌病的临床治疗。
EMBO Mol Med. 2022 Aug 8;14(8):e16423. doi: 10.15252/emmm.202216423.
2
Modeling hypertrophic cardiomyopathy with human cardiomyocytes derived from induced pluripotent stem cells.利用诱导多能干细胞衍生的人心肌细胞构建肥厚型心肌病模型。
Stem Cell Res Ther. 2022 Jun 3;13(1):232. doi: 10.1186/s13287-022-02905-0.
3
Ion Channel Impairment and Myofilament Ca Sensitization: Two Parallel Mechanisms Underlying Arrhythmogenesis in Hypertrophic Cardiomyopathy.
离子通道功能障碍和肌球蛋白钙敏化：肥厚型心肌病心律失常发生的两个并行机制。
Cells. 2021 Oct 18;10(10):2789. doi: 10.3390/cells10102789.
4
Translational investigation of electrophysiology in hypertrophic cardiomyopathy.肥厚型心肌病电生理学的转化研究。
J Mol Cell Cardiol. 2021 Aug;157:77-89. doi: 10.1016/j.yjmcc.2021.04.009. Epub 2021 May 3.
5
Cardiac Late Sodium Channel Current Is a Molecular Target for the Sodium/Glucose Cotransporter 2 Inhibitor Empagliflozin.心脏晚期钠通道电流是钠/葡萄糖协同转运蛋白 2 抑制剂恩格列净的分子靶标。
Circulation. 2021 Jun;143(22):2188-2204. doi: 10.1161/CIRCULATIONAHA.121.053350. Epub 2021 Apr 9.
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