不同细胞色素P-450同工酶在各种底物去甲基化中的作用。
Role of different cytochrome P-450 isozymes in the demethylation of various substrates.
作者信息
Hietanen E, Kobljakov V, Bartsch H
出版信息
Gen Pharmacol. 1986;17(5):565-8. doi: 10.1016/0306-3623(86)90094-7.
Phenobarbital treatment of rats enhanced 2-fold the hepatic aninopyrine (AP) and dimethylhydrazine (DMH) demethylation but not that of N-nitrosodimethylamine (NDMA). Pyrazole enhanced the demethylation rate of DMH and NDMA but not that of AP. The in vitro effects of metyrapone and SKF-525A on the demethylation rate of various substrates were dependent on the substrate and treatment of rats. The data suggest that the demethylation of various substrates might be catalyzed by different cytochrome P-450 isozymes.
用苯巴比妥治疗大鼠可使肝脏中氨基比林（AP）和二甲基肼（DMH）的脱甲基作用增强2倍，但对N-亚硝基二甲基胺（NDMA）的脱甲基作用无增强效果。吡唑可提高DMH和NDMA的脱甲基速率，但对AP的脱甲基速率无影响。甲吡酮和SKF-525A对各种底物脱甲基速率的体外作用取决于底物及大鼠的治疗情况。数据表明，各种底物的脱甲基作用可能由不同的细胞色素P-450同工酶催化。
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