Yang C S, Tu Y Y, Hong J, Patten C
IARC Sci Publ. 1984(57):423-8.
Results are presented to show that N-nitrosodimethylamine demethylase is P-450 mediated and N-nitrosodimethylamine is efficiently metabolized by specific P-450 isozymes inducible by a group of new inducers. The P-450-mediated N-nitrosodimethylamine demethylase also responds differently to inhibitors when activities are compared with those of classical monooxygenase systems.
结果表明，N-亚硝基二甲胺脱甲基酶由P-450介导，并且N-亚硝基二甲胺可被一组新型诱导剂诱导的特定P-450同工酶有效代谢。当将P-450介导的N-亚硝基二甲胺脱甲基酶的活性与经典单加氧酶系统的活性进行比较时，其对抑制剂的反应也有所不同。
