Zhang S H, Wang X J, Jiang Z F
Zhonghua Yi Xue Za Zhi. 2023 Oct 17;103(38):2993-3001. doi: 10.3760/cma.j.cn112137-20230616-01027.
Endocrine therapy is the primary systemic therapy for hormone receptor-positive breast cancer, which runs through the whole process of treatment for early and metastatic breast cancer. The development of new endocrine agents and targeted drugs such as cyclin-dependent kinases 4/6(CDK4/6)inhibitors has improved outcome of patients with hormone receptor-positive breast cancer and changed the treatment landscape. The update of clinical research data provides more treatment options, calling for treatment optimization. Experts had a deep discussion around the hot topics on endocrine therapy of breast cancer, and formulated the'Expert consensus on endocrine therapy of breast cancer (2023 edition)'.This consensus is based on research data worldwide and clinical practice experience, with the aims of standardizing clinical diagnosis and optimizing treatment in neoadjuvant, adjuvant and metastatic setting of hormone receptor-positive breast cancer.
内分泌治疗是激素受体阳性乳腺癌的主要全身治疗方法,贯穿于早期和转移性乳腺癌的整个治疗过程。新型内分泌药物和靶向药物如细胞周期蛋白依赖性激酶4/6(CDK4/6)抑制剂的出现改善了激素受体阳性乳腺癌患者的预后,并改变了治疗格局。临床研究数据的更新提供了更多治疗选择,需要优化治疗方案。专家们围绕乳腺癌内分泌治疗的热点话题进行了深入讨论,并制定了《乳腺癌内分泌治疗专家共识(2023版)》。该共识基于全球研究数据和临床实践经验,旨在规范激素受体阳性乳腺癌新辅助、辅助和转移性治疗中的临床诊断并优化治疗。