Chengdu University of TCM, Sichuan, China.
Hospital of Chengdu University of TCM, Sichuan, China.
BMC Med Genomics. 2023 Oct 9;16(1):238. doi: 10.1186/s12920-023-01673-x.
This study aims to investigate the potential bidirectional causal relationship between myopia and vitreous disorders from a genetic perspective, as vitreous disorders have been found to be closely associated with myopia development.
To achieve this, a two-sample Mendelian randomization (MR) design was employed. The study utilized pooled statistics from independent genome-wide association studies. Myopia was chosen as the exposure factor, while five different vitreous disorders were considered as outcomes. The primary analytical method was the inverse variance weighting (IVW) method, supplemented by sensitivity analysis.
The study yielded significant findings indicating a positive association between myopia and vitreous disorders. The genetic prediction of myopia consistently demonstrated a positive correlation with vitreous disorders, as evidenced by IVW (odds ratio [OR] = 18.387; P < 0.01), MR Egger (OR = 2784.954; P < 0.01), weighted median (OR = 30.284; P < 0.01), and weighted mode (OR = 57.381; P < 0.01). All sensitivity analyses further validated these associations. Furthermore, a significant association was observed between myopia and other unspecified vitreous body disorders (IVW: OR = 57.729; P < 0.01).
Studies mainly conducted in European populations have confirmed that myopia, extending beyond early high myopia, plays a crucial role in influencing vitreous disorders and that there is a unidirectional causal relationship between myopia and vitreous disorders. Additionally, a causal relationship was identified between myopia and other unspecified vitreous disordes. These findings introduce fresh perspectives for the clinical management of unspecified vitreous disorders and contribute to the understanding of the effect of myopia on vitreous disorders. Myopia prevention and treatment will aid in slowing down the process of vitreous liquefaction and subsequently decrease the incidence of malignant eye conditions.
本研究旨在从遗传角度探讨近视与玻璃体疾病之间潜在的双向因果关系，因为已经发现玻璃体疾病与近视的发展密切相关。
为此，采用了两样本孟德尔随机化（MR）设计。该研究利用了来自独立全基因组关联研究的汇总统计数据。近视被选为暴露因素，而五种不同的玻璃体疾病被视为结果。主要分析方法是逆方差加权（IVW）法，并辅以敏感性分析。
研究结果表明，近视与玻璃体疾病之间存在正相关。近视的遗传预测与玻璃体疾病始终呈正相关，IVW（比值比[OR] = 18.387；P < 0.01）、MR Egger（OR = 2784.954；P < 0.01）、加权中位数（OR = 30.284；P < 0.01）和加权模式（OR = 57.381；P < 0.01）均得到证实。所有敏感性分析进一步验证了这些关联。此外，还观察到近视与其他未指定玻璃体疾病之间存在显著关联（IVW：OR = 57.729；P < 0.01）。
主要在欧洲人群中进行的研究证实，超出早期高度近视的近视程度对玻璃体疾病有重要影响，并且近视与玻璃体疾病之间存在单向因果关系。此外，还确定了近视与其他未指定玻璃体疾病之间存在因果关系。这些发现为未指定玻璃体疾病的临床管理引入了新的视角，并有助于理解近视对玻璃体疾病的影响。近视的预防和治疗将有助于减缓玻璃体液化的进程，从而降低恶性眼病的发病率。
