State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Curr Eye Res. 2020 Jan;45(1):104-110. doi: 10.1080/02713683.2019.1646772. Epub 2019 Aug 13.
: Dickkopf 1 (DKK1) functions as a natural antagonist of the canonical Wnt/β-catenin pathway. The purpose of this study was to examine the expression of DKK1 in vitreous samples of patients with pathological myopia, in order to search for possible correlations between DKK1 and axial length.: The expression of DKK1 and other cytokines in vitreous samples of 44 non-myopic eyes, 42 eyes with low-to-moderate myopia, and 51 eyes with pathological myopia were examined using multiplex cytokine detection technology. Ophthalmologic characteristics, including axial length and subfoveal choroidal thickness, were clinically measured for further analysis.: The intravitreous levels of DKK1 ( < .0001) were markedly higher in the pathological myopia group than in the control group. There were no differences of DKK1 levels in different vitreoretinal conditions. Additionally, we found that the DKK1 levels were positively correlated with HGF (β = 0.268, = .032), and TIMP-3 (β = 0.209, = .047) levels, as well as with axial length (β = 0.714, < .0001) in the pathological myopia group.: Elevated levels of DKK1 were found in the eyes with elongated axial length.
DKK1（Dickkopf 1）作为经典 Wnt/β-catenin 通路的天然拮抗剂发挥作用。本研究旨在检测病理性近视患者眼内液中 DKK1 的表达，以寻找 DKK1 与眼轴长度之间的可能相关性。
采用多重细胞因子检测技术，检测了 44 只非近视眼、42 只中低度近视眼和 51 只病理性近视眼中 DKK1 和其他细胞因子的表达。对眼科特征（包括眼轴长度和中心凹下脉络膜厚度）进行临床测量，以便进一步分析。
结果表明，病理性近视组眼内液中 DKK1 水平明显高于对照组（<0.0001）。不同的玻璃体视网膜状况下 DKK1 水平无差异。此外，我们发现病理性近视组中 DKK1 水平与 HGF（β=0.268， =0.032）和 TIMP-3（β=0.209， =0.047）水平呈正相关，与眼轴长度（β=0.714， <0.0001）呈正相关。
在眼轴延长的眼中发现了升高的 DKK1 水平。
