Lu Yongping, Fan Linming, Wang Jun, Hu Mingxiang, Wei Baogang, Shi Ping, Li Jianshu, Feng Jinyan, Zheng Yu
Science and Technologv Innovation Center, Guangyuan Central Hospital, Guangyuan, 628000, China.
Guangyuan Key Laboratory of Multifunctional Medical Hydrogel, Guangyuan Central Hospital, Guangyuan, 628000, China.
Small. 2024 Feb;20(7):e2306540. doi: 10.1002/smll.202306540. Epub 2023 Oct 9.
The nanodelivery system provides a novel direction for disease diagnosis and treatment; however, its delivery effectiveness is restricted by the short biological half-life and inadequate tumor targeting. The immune evasion properties and homologous targeting capabilities of natural cell membranes, particularly those of cancer cell membranes (CCM), have gained significant interest. The integration of CCM and nanoparticles has resulted in the emergence of CCM-based nanoplatforms (CCM-NPs), which have gained significant attention due to their unique properties. CCM-NPs not only prolong the blood circulation time of core nanoparticles, but also direct them for homologous tumor targeting. Herein, the history and development of CCM-NPs as well as how these platforms have been used for biomedical applications are discussed. The application of CCM-NPs for cancer therapy will be described in detail. Translational efforts are currently under way and further research to address key areas of need will ultimately be required to facilitate the successful clinical adoption of CCM-NPs.
纳米递送系统为疾病的诊断和治疗提供了新的方向；然而，其递送效果受到生物半衰期短和肿瘤靶向性不足的限制。天然细胞膜，尤其是癌细胞膜（CCM）的免疫逃逸特性和同源靶向能力引起了人们的极大兴趣。CCM与纳米颗粒的整合导致了基于CCM的纳米平台（CCM-NPs）的出现，这些纳米平台因其独特的性质而备受关注。CCM-NPs不仅延长了核心纳米颗粒的血液循环时间，还引导它们进行同源肿瘤靶向。本文讨论了CCM-NPs的历史和发展，以及这些平台如何用于生物医学应用。将详细描述CCM-NPs在癌症治疗中的应用。目前正在进行转化研究，最终需要进一步研究以解决关键需求领域，以促进CCM-NPs在临床上的成功应用。
