Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, 11031, Taiwan.
International PhD Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, 11031, Taiwan.
Int J Nanomedicine. 2023 Oct 4;18:5607-5623. doi: 10.2147/IJN.S404394. eCollection 2023.
Due to their non-toxic function in biological systems, Iron oxide NPs (IO-NPs) are very attractive in biomedical applications. The magnetic properties of IO-NPs enable a variety of biomedical applications. We evaluated the usage of IO-NPs for anticancer effects. This paper lists the applications of IO-NPs in general and the clinical targeting of IO-NPs. The application of IONPs along with photothermal therapy (PTT), photodynamic therapy (PDT), and magnetic hyperthermia therapy (MHT) is highlighted in this review's explanation for cancer treatment strategies. The review's study shows that IO-NPs play a beneficial role in biological activity because of their biocompatibility, biodegradability, simplicity of production, and hybrid NPs forms with IO-NPs. In this review, we have briefly discussed cancer therapy and hyperthermia and NPs used in PTT, PDT, and MHT. IO-NPs have a particular effect on cancer therapy when combined with PTT, PDT, and MHT were the key topics of the review and were covered in depth. The IO-NPs formulations may be uniquely specialized in cancer treatments with PTT, PDT, and MHT, according to this review investigation.
由于其在生物系统中的无毒功能，氧化铁纳米粒子（IO-NPs）在生物医学应用中非常有吸引力。IO-NPs 的磁性使其能够应用于多种生物医学领域。我们评估了 IO-NPs 在抗癌方面的应用。本文列出了 IO-NPs 的一般应用和临床靶向应用。本文的解释强调了 IO-NPs 与光热疗法（PTT）、光动力疗法（PDT）和磁热疗（MHT）的联合应用，以治疗癌症。本综述研究表明，IO-NPs 由于其生物相容性、生物降解性、生产简单性以及与 IO-NPs 的杂化 NPs 形式，在生物活性中发挥着有益的作用。在本综述中，我们简要讨论了癌症治疗和热疗以及用于 PTT、PDT 和 MHT 的 NPs。当与 PTT、PDT 和 MHT 联合使用时，IO-NPs 对癌症治疗具有特殊作用，这是本综述的重点，并进行了深入探讨。根据本综述的研究，IO-NPs 制剂可能在 PTT、PDT 和 MHT 治疗癌症方面具有独特的优势。
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