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槲皮素-铁(Fe)络合物的合成及其抗菌活性的确证

Synthesis of quercetin-iron (Fe) complex and its and confirmation towards antibacterial activity.

作者信息

Khagar Prerna, Wankhade Atul V, Sabarathinam Sarvesh

机构信息

Department of Chemistry, Visvesvaraya National Institute of Technology, Nagpur, 440010 (MS), India.

Drug Testing Laboratory (DTL), Interdisciplinary Institute of Indian System of Medicine (IIISM), SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamil Nadu-603203, India.

出版信息

Future Med Chem. 2023 Oct;15(19):1743-1756. doi: 10.4155/fmc-2023-0007. Epub 2023 Oct 10.

Abstract

In this study quercetin-iron complex (QFC) was synthesized, and the structural characterizations such as x-ray diffraction, field emission-scanning electron microscopy, energy-dispersive x-ray and Brunner-Emmitt-Teller adsorption-desorption isotherm analysis revealed the crystallinity state, surface morphology and nature of the adsorbing surface with surface area value. Functional characterizations such as UV-visible spectrometric and Fourier transform infrared analysis collectively indicated the chemical changes that appeared after complex formation in terms of characteristic change in the spectrum and band position, respectively. The antibacterial activity against and has shown a dose-dependent decrease in colony count and achieved significant removal at 15 mg/ml concentration of QFC. The molecular docking study supports the therapeutic application of QFC.

摘要

在本研究中,合成了槲皮素-铁络合物(QFC),通过X射线衍射、场发射扫描电子显微镜、能量色散X射线和布鲁诺尔-埃米特-泰勒吸附-脱附等温线分析等结构表征揭示了其结晶状态、表面形态以及具有表面积值的吸附表面性质。紫外可见光谱和傅里叶变换红外分析等功能表征分别从光谱特征变化和谱带位置方面共同表明了络合物形成后出现的化学变化。对[具体细菌名称1]和[具体细菌名称2]的抗菌活性表明,菌落计数呈剂量依赖性下降,在QFC浓度为15mg/ml时实现了显著清除。分子对接研究支持了QFC的治疗应用。

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