Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Shanghai center of Thyroid diseases, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Free Radic Res. 2023 May-Jun;57(6-12):395-403. doi: 10.1080/10715762.2023.2265054. Epub 2023 Dec 26.
To investigate the cross-sectional and longitudinal correlation between serum superoxide dismutase (SOD) levels and thyroid function with obesity before and after laparoscopic sleeve gastrectomy (LSG). Patients with morbid obesity ( = 219, 112 males and 107 females) who underwent LSG were selected and they were subdivided into normal levels of SOD (NSOD, = 112) and high levels of SOD (HSOD, = 107) according to the median value of SOD levels (183 U/mL). SOD and thyroid hormones were measured and compared at baseline, 3, 6, and 12 months after LSG. The HSOD group had lower body mass index (BMI), total thyroxine (TT4), and thyroid-stimulating hormone (TSH) than the NSOD group ( < 0.001, = 0.031, < 0.001, respectively). However, they had higher free triiodothyronine (FT3) and free thyroxine (FT4) ( = 0.019 and = 0.017, respectively). SOD was significantly negatively associated with TSH and positively associated with FT4. Of all the patients, 22.31% (NSOD: 66.67%; HSOD: 33.33%) had subclinical hypothyroidism (SH), and there were lower SOD levels in the SH group. Preoperative SOD was a protective factor for SH. After LSG, SOD and FT4 levels were increased at 12 months after LSG, however, TSH, FT3, total triiodothyronine (TT3) and TT4 levels decreased compared to the preoperative levels at 3, 6, and 12 months in the SH group. Postoperative changes in FT4 and TT4 levels correlated with changes in SOD levels. SOD, which is correlated with thyroid hormones, protects against SH in patients with obesity. The improvement in thyroid function with SH after LSG may be related to increased SOD levels.
研究腹腔镜袖状胃切除术（LSG）前后血清超氧化物歧化酶（SOD）水平与甲状腺功能与肥胖的横断面和纵向相关性。
选择 219 例病态肥胖患者（112 例男性和 107 例女性）进行 LSG，并根据 SOD 水平中位数（183 U/mL）将患者分为正常 SOD 组（NSOD，n=112）和高 SOD 组（HSOD，n=107）。分别在基线、LSG 后 3、6 和 12 个月测量 SOD 和甲状腺激素，并进行比较。
HSOD 组的体重指数（BMI）、总甲状腺素（TT4）和促甲状腺激素（TSH）低于 NSOD 组（均 P<0.001，=0.031，P<0.001），而游离三碘甲状腺原氨酸（FT3）和游离甲状腺素（FT4）高于 NSOD 组（均 P<0.001）。SOD 与 TSH 呈显著负相关，与 FT4 呈显著正相关。所有患者中，22.31%（NSOD：66.67%；HSOD：33.33%）患有亚临床甲状腺功能减退症（SH），SH 组的 SOD 水平较低。术前 SOD 是 SH 的保护因素。LSG 后，SH 组在 LSG 后 12 个月时 SOD 和 FT4 水平升高，而在 3、6 和 12 个月时 TSH、FT3、总三碘甲状腺原氨酸（TT3）和 TT4 水平较术前降低。SH 组 FT4 和 TT4 水平的术后变化与 SOD 水平的变化相关。SOD 与甲状腺激素相关，可预防肥胖患者发生 SH。LSG 后 SH 甲状腺功能的改善可能与 SOD 水平的升高有关。
