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小鼠对二硝基氟苯的接触性细胞介导免疫反应和IgE超敏反应的分离免疫抑制作用

Split immunosuppression of contact cell-mediated and of IgE hypersensitivity responses to dinitrofluorobenzene in mice.

作者信息

Ben-Efraim S, Mor S, Gal T, Ben-David A, Gitter S

出版信息

Int Arch Allergy Appl Immunol. 1986;81(4):326-30. doi: 10.1159/000234157.

DOI:10.1159/000234157
PMID:3781640
Abstract

Contact sensitivity (CS), anti-DNP (dinitrophenyl) IgG and IgE type antibodies were induced by skin applications of the contact sensitizer dinitrofluorobenzene. CS response was suppressed by treatment with the monovalent hapten dinitrobenzene sulfonate (DNBS) but was not affected by treatment with the DNP-conjugates (DNP22-Ficoll, DNP17-polyethylene glycol and DNP2-polyvinylpyrrolidone). On the other hand, IgE type response was depressed by treatment with the various DNP conjugates but was not affected by DNBS. The IgG type response was not appreciably affected by any of the treatments.

摘要

通过皮肤涂抹接触致敏剂二硝基氟苯诱导接触性敏感(CS)、抗二硝基苯基(DNP)IgG和IgE型抗体。用单价半抗原二硝基苯磺酸盐(DNBS)处理可抑制CS反应,但用DNP缀合物(DNP22 - 菲可、DNP17 - 聚乙二醇和DNP2 - 聚乙烯吡咯烷酮)处理则无影响。另一方面,用各种DNP缀合物处理可降低IgE型反应,但DNBS处理无影响。IgG型反应不受任何一种处理的明显影响。

相似文献

1
Split immunosuppression of contact cell-mediated and of IgE hypersensitivity responses to dinitrofluorobenzene in mice.小鼠对二硝基氟苯的接触性细胞介导免疫反应和IgE超敏反应的分离免疫抑制作用
Int Arch Allergy Appl Immunol. 1986;81(4):326-30. doi: 10.1159/000234157.
2
Contact hypersensitivity reactions to dinitrofluorobenzene mediated by monoclonal IgE anti-DNP antibodies.由单克隆IgE抗二硝基苯抗体介导的对二硝基氟苯的接触性超敏反应。
J Immunol. 1983 Sep;131(3):1096-102.
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Influence of contact sensitivity to DNFB on the induction of carrier-determined tolerance to DNP.对二硝基氟苯的接触敏感性对诱导载体决定的对二硝基苯基耐受性的影响。
Cell Immunol. 1976 Oct;26(2):135-40. doi: 10.1016/0008-8749(76)90357-9.
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Antigen receptors on murine T lymphocytes in contact sensitivity. I. Functional inhibition of effector T cells by monovalent 2,4-dinitrophenol: implication for a two-receptor model.接触敏感性中鼠T淋巴细胞上的抗原受体。I. 单价2,4-二硝基苯酚对效应T细胞的功能抑制:对双受体模型的启示
J Exp Med. 1981 Dec 1;154(6):1811-26. doi: 10.1084/jem.154.6.1811.
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Genetic restrictions for the induction of suppressor T cells by hapten-modified lymphoid cells in tolerance to 1-fluoro-2,4-dinitrobenzene contact sensitivity. Role of the H-2D region of the major histocompatibility complex.在对1-氟-2,4-二硝基苯接触敏感性的耐受性中,半抗原修饰的淋巴细胞诱导抑制性T细胞的遗传限制。主要组织相容性复合体H-2D区域的作用。
J Exp Med. 1978 Mar 1;147(3):788-99. doi: 10.1084/jem.147.3.788.
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Antigen receptors on murine T lymphocytes in contact sensitivity. II. Presentation and characterization of syngeneic anti-idiotype serum against DNFB-sensitized T cells.接触敏感性中鼠T淋巴细胞上的抗原受体。II. 针对二硝基氟苯致敏T细胞的同基因抗独特型血清的呈现与特性分析
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Regulation of cell mediated immunity by antibodies: possible role of anti-receptor antibodies in the regulation of contact sensitivity to DNFB in mice.
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Suppressor T-cell mechanisms in contact sensitivity. III. Apparent non-major histocompatibility complex restriction is a result of multiple sets of major histocompatibility complex-specific suppressor T cells induced by syngeneic 2,4-dinitrophenyl-modified lymphoid cells.接触敏感性中的抑制性T细胞机制。III. 明显的非主要组织相容性复合体限制是由同基因2,4-二硝基苯基修饰的淋巴细胞诱导的多组主要组织相容性复合体特异性抑制性T细胞的结果。
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Soluble factors in tolerance and contact sensitivity to 2,4-dinitrofluorobenzene in mice. I. Suppression of contact sensitivity by soluble suppressor factor released in vitro by lymph node cell populations containing specific suppressor cells.小鼠对2,4-二硝基氟苯的耐受性和接触敏感性中的可溶性因子。I. 含有特异性抑制细胞的淋巴结细胞群体在体外释放的可溶性抑制因子对接触敏感性的抑制作用。
J Immunol. 1977 Jul;119(1):315-21.