Bonavita E
Int J Clin Pharmacol Ther Toxicol. 1986 Sep;24(9):511-6.
The aim of this study was to evaluate the efficacy and tolerability of L-acetylcarnitine therapy in the senile brain. The trial was conducted on a double-blind basis, with a total of 40 patients divided into two groups of 20, treated for 40 days with L-acetylcarnitine and placebo, respectively--the therapeutic regimen being two 500 mg tablets t.i.d. Mental parameters of the senile brain were assessed at 0, 20 and 40 days of treatment, while basal and final values were recorded for a number of laboratory tests. Statistical analysis of results confirmed that short-term, intensive L-acetylcarnitine treatment can determine a significant improvement of the main mental parameters of the senile brain, without incidence of significant side effects.
本研究的目的是评估L-乙酰肉碱疗法对老年大脑的疗效和耐受性。该试验采用双盲方式进行，共有40名患者，分为两组，每组20人，分别接受L-乙酰肉碱和安慰剂治疗40天，治疗方案为每日三次，每次两片500毫克片剂。在治疗的第0、20和40天评估老年大脑的精神参数，同时记录多项实验室检查的基础值和最终值。结果的统计分析证实，短期、强化的L-乙酰肉碱治疗可显著改善老年大脑的主要精神参数，且无明显副作用。
