Chen Liangkai, Wang Qiang, Lv Yanling, Xu Wenyuan, Jiang Guanhua, Li Yonggang, Luo Ping, He Ruikun, Liu Liegang
Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Diabetes Metab Res Rev. 2024 Feb;40(2):e3735. doi: 10.1002/dmrr.3735. Epub 2023 Oct 10.
Population-based evidence regarding circulating advanced glycation end-products (AGEs) and the risk of type 2 diabetes (T2D) is conflicting and insufficient. We aimed to examine the association of plasma AGEs and plasma soluble receptors for AGEs (sRAGE) with T2D.
We conducted a hospital-based case-control study including 1072 pairs (53.9 ± 9.7 years, 56.0% male) of newly diagnosed T2D and age- and sex-matched controls. We further performed a nested case-control study within an ongoing prospective cohort consisting of 127 incident T2D cases and 381 well-matched controls (62.2 ± 5.1 years, 71.7% male). Plasma AGEs were detected using liquid chromatography-tandem mass spectrometry, and plasma sRAGE was measured by enzyme-linked immunosorbent assay. Conditional logistic regression was used to evaluate the association of plasma AGEs and sRAGE concentrations with T2D.
Higher plasma AGEs and lower sRAGE concentrations were associated with higher odds of T2D. The multivariable-adjusted odds ratios of T2D comparing the highest with the lowest quartile levels were 3.28 (95% CI: 2.14, 5.02) for plasma AGEs and 0.25 (95% CI: 0.16, 0.39) for plasma sRAGE. Participants in the highest quartile of plasma AGEs and the lowest quartile of sRAGE concentrations had the greatest odds of T2D. The positive association of AGEs and inverse association of sRAGE with T2D risk was confirmed in the replication-nested case-control study.
Increased circulating AGEs and decreased sRAGE concentrations were associated with elevated T2D risk. Our findings may have implications for the strategies of T2D prevention and management.
基于人群的关于循环晚期糖基化终产物（AGEs）与2型糖尿病（T2D）风险的证据相互矛盾且不充分。我们旨在研究血浆AGEs和血浆可溶性AGE受体（sRAGE）与T2D的关联。
我们开展了一项基于医院的病例对照研究，纳入1072对（年龄53.9±9.7岁，男性占56.0%）新诊断的T2D患者及年龄和性别匹配的对照。我们还在一项正在进行的前瞻性队列中进行了巢式病例对照研究，该队列包括127例T2D新发病例和381例匹配良好的对照（年龄62.2±5.1岁，男性占71.7%）。采用液相色谱 - 串联质谱法检测血浆AGEs，用酶联免疫吸附测定法测量血浆sRAGE。使用条件逻辑回归评估血浆AGEs和sRAGE浓度与T2D的关联。
较高的血浆AGEs水平和较低的sRAGE浓度与T2D的较高发病几率相关。将最高四分位数水平与最低四分位数水平相比，T2D的多变量调整比值比，血浆AGEs为3.28（95%置信区间：2.14，5.02），血浆sRAGE为0.25（95%置信区间：0.16，0.39）。血浆AGEs处于最高四分位数且sRAGE浓度处于最低四分位数的参与者患T2D的几率最大。在重复巢式病例对照研究中证实了AGEs与T2D风险的正相关以及sRAGE与T2D风险的负相关。
循环AGEs增加和sRAGE浓度降低与T2D风险升高相关。我们的研究结果可能对T2D的预防和管理策略具有启示意义。
