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肺手术后的非计划性再次手术:单中心的发生率、危险因素及早期结局

Unplanned reoperation after pulmonary surgery: Rate, risk factors and early outcomes at a single center.

作者信息

Xu Kuan, Xie Ermei, Lv Yilv, Gu Wei, Shi Minjun, Yao Jueya, Wu Jingxiang, Ye Bo

机构信息

Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.

Key Laboratory of Synthetic Biology Regulatory Element, Institute of Systems Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

出版信息

Heliyon. 2023 Sep 30;9(10):e20538. doi: 10.1016/j.heliyon.2023.e20538. eCollection 2023 Oct.

Abstract

BACKGROUND

Unplanned reoperation is a potential risk factor for worse prognoses and reflects the quality of surgical treatment. This study compared the short-term outcomes between patients with and without reoperation and identified clinical factors predicting reoperation within 90 days following pulmonary surgery.

METHODS

Consecutive patients undergoing pulmonary resection from January 2012 to August 2021 at our institution were retrospectively reviewed. Clinical and operation-related data were collected and analyzed. Kaplan‒Meier, Cox hazard proportional regression, and propensity score matching were adopted for prognostic evaluation.

RESULTS

A total of 90263 patients were included: 247 (0.27%) patients required reoperation within 90 days. Patients undergoing unplanned reoperation had higher mortality and more postoperative complications than the nonreoperation group. Reoperation within 24 h was associated with reduced odds of mortality relative to reoperation beyond 24 h. Independent risk factors for unplanned reoperation were male sex, benign lung disease, specific surgical locations, lobectomy, and pneumonectomy. A history of smoking, pulmonary tuberculosis, intraoperative pleural adhesion, and postoperative complications were also identified as predisposing factors. The most common complication was hemorrhage in 75.7% (187 of 247).

CONCLUSION

Our study found that unplanned reoperation was a rare but serious event that increased the risk of postoperative complications and mortality. We identified several risk factors that could be used to stratify patients according to their reoperation risk and suggest that high-risk patients should receive more intensive monitoring and preventive measures. Moreover, our study indicated that reoperating within 24 h could improve the outcomes for patients who needed reoperation.

摘要

背景

非计划性再次手术是预后较差的一个潜在风险因素,反映了外科治疗的质量。本研究比较了接受再次手术和未接受再次手术患者的短期结局,并确定了预测肺手术后90天内再次手术的临床因素。

方法

回顾性分析2012年1月至2021年8月在我院接受肺切除术的连续患者。收集并分析临床和手术相关数据。采用Kaplan-Meier法、Cox风险比例回归法和倾向得分匹配法进行预后评估。

结果

共纳入90263例患者,其中247例(0.27%)在90天内需要再次手术。与未再次手术组相比,接受非计划性再次手术的患者死亡率更高,术后并发症更多。与24小时后再次手术相比,24小时内再次手术与死亡率降低相关。非计划性再次手术的独立危险因素包括男性、良性肺病、特定手术部位、肺叶切除术和全肺切除术。吸烟史、肺结核、术中胸膜粘连和术后并发症也被确定为诱发因素。最常见的并发症是出血,占75.7%(247例中的187例)。

结论

我们的研究发现,非计划性再次手术是一种罕见但严重的事件,会增加术后并发症和死亡风险。我们确定了几个风险因素,可用于根据患者再次手术的风险进行分层,并建议高危患者应接受更密切的监测和预防措施。此外,我们的研究表明,24小时内再次手术可以改善需要再次手术患者的结局。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de60/10560774/6a88d3ca8b82/gr1.jpg

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