核苷类抗生素与鸟嘌呤7 - N - 氧化物联合对弹状病毒——传染性造血器官坏死病毒（IHNV）的协同作用。

The synergism of nucleoside antibiotics combined with guanine 7-N-oxide against a rhabdovirus, infectious hematopoietic necrosis virus (IHNV).

作者信息

Hasobe M, Saneyoshi M, Isono K

出版信息

J Antibiot (Tokyo). 1986 Sep;39(9):1291-7. doi: 10.7164/antibiotics.39.1291.

DOI:10.7164/antibiotics.39.1291

PMID:3781928

Abstract

Guanine 7-N-oxide was shown to have synergistic activity in combination with neplanocin A against a rhabdovirus, infectious hematopoietic necrosis virus (IHNV), as reported previously. We examined further the antiviral activity of guanine 7-N-oxide in combination with other nucleoside antibiotics against IHNV. Synergism was seen between guanine 7-N-oxide and D-eritadenine or cordycepin. It is considered that compounds inhibiting RNA methylation show synergism with guanine 7-N-oxide.

摘要

如先前报道，鸟嘌呤7 - N - 氧化物与奈拉滨联合使用时，对弹状病毒——传染性造血坏死病毒（IHNV）具有协同活性。我们进一步研究了鸟嘌呤7 - N - 氧化物与其他核苷类抗生素联合使用对IHNV的抗病毒活性。结果发现鸟嘌呤7 - N - 氧化物与D - 赤藓嘌呤或虫草素之间存在协同作用。据认为，抑制RNA甲基化的化合物与鸟嘌呤7 - N - 氧化物具有协同作用。