Lions Eye Institute, Department of Ophthalmology, Albany Medical College, Albany, NY, USA.
Department of Otolaryngology, Albany Medical College, Albany, NY, USA.
Graefes Arch Clin Exp Ophthalmol. 2024 Feb;262(2):609-614. doi: 10.1007/s00417-023-06268-x. Epub 2023 Oct 11.
Previous investigations into the relationship between season and the incidence of giant cell arteritis (GCA) have produced conflicting results. This study aimed to explore the impact of season and new diagnoses of GCA in a more definitive sense by employing the large dataset of the Intelligent Research in Sight (IRIS) database.
The IRIS Registry was queried to identify new cases of GCA from 2013 to 2021. Statistical analyses were performed to determine the significance of the relationship between the time of year and the incidence of GCA on regional and nationwide bases via Cochran's Q statistical test.
A total of 27,339 eyes with a new diagnosis of GCA were identified. Neither the month nor the season of the year correlated with the incidence of GCA, regardless of geographic location within the USA (p > 0.05 for each variable).
In the USA, the incidence of GCA does not appear to vary by month or season. While this finding contradicts certain previous studies that identified a relationship, the cohort of patients identified from the IRIS Registry is much larger than that of previous investigations. Clinicians should be mindful of the possibility of GCA, regardless of the time of the year.
先前关于季节与巨细胞动脉炎（GCA）发病之间关系的研究结果相互矛盾。本研究旨在通过利用 Intelligent Research in Sight（IRIS）数据库中的大型数据集，更明确地探讨季节和新诊断的 GCA 之间的影响。
对 IRIS 登记处进行查询，以确定 2013 年至 2021 年间新诊断的 GCA 病例。通过 Cochran's Q 统计检验，在区域和全国范围内对季节与 GCA 发病率之间的关系进行统计学分析，以确定其显著性。
共确定了 27339 只患有新诊断的 GCA 的眼睛。无论在美国的地理位置如何（每个变量的 p 值均>0.05），月份或季节均与 GCA 的发病率无关。
在美国，GCA 的发病率似乎不受月份或季节的影响。虽然这一发现与某些先前确定存在相关性的研究相矛盾，但从 IRIS 登记处确定的患者队列比以往的研究要大得多。无论何时，临床医生都应注意 GCA 的可能性。
