多样化的优势：扩大 B 细胞募集以实现更广泛的疫苗保护。
Strength in diversity: Widening B cell recruitment for broader vaccine protection.
机构信息
Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.
Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia; Melbourne Sexual Health Centre and Department of Infectious Diseases, Alfred Hospital and Central Clinical School, Monash University, Melbourne, VIC, Australia.
出版信息
Immunity. 2023 Oct 10;56(10):2182-2184. doi: 10.1016/j.immuni.2023.09.009.
Generating potent neutralizing antibodies is a unifying goal of next-generation vaccines. In this issue of Immunity, Ols et al. show that multivalent nanoparticle vaccines displaying RSV F protein can enable recruitment of more diverse B cell specificities into the vaccine response, resulting in increased potency and breadth of antibody immunity to both RSV and the related human metapneumovirus.
产生高效的中和抗体是下一代疫苗的统一目标。在本期《免疫》中，Ols 等人表明，展示 RSV F 蛋白的多价纳米颗粒疫苗可以招募更多不同的 B 细胞特异性进入疫苗反应，从而提高对 RSV 和相关人偏肺病毒的抗体免疫的效力和广度。
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