Inoue A, Higashi Y, Hasuma T, Yukioka M, Morisawa S
J Biochem. 1986 Sep;100(3):747-51. doi: 10.1093/oxfordjournals.jbchem.a121767.
A unique and simple set of proteins (S1 proteins) has been detected in the cell nuclei of various tissues of the rat (Inoue et al. (1983) Eur. J. Biochem. 135, 61-68). They were liberated from the nuclei by digestion with DNA-hydrolyzing enzymes under the conditions where transcriptionally active chromatin is preferentially digested and released into the reaction supernatant. S1 proteins account for 20% of the total supernatant proteins (Higashi et al. (1984) Biochem. Int. 9, 697-704). The present study demonstrates that S1 proteins occur at the sites sensitive to RNase A as well as DNase I, and are rapidly liberated from the nuclei by digestion with either enzyme.
在大鼠各种组织的细胞核中检测到了一组独特而简单的蛋白质（S1蛋白）（井上等人，(1983)《欧洲生物化学杂志》135卷，61 - 68页）。在转录活性染色质被优先消化并释放到反应上清液中的条件下，通过用DNA水解酶消化，它们从细胞核中释放出来。S1蛋白占上清液总蛋白的20%（东等人，(1984)《生物化学国际》9卷，697 - 704页）。本研究表明，S1蛋白出现在对核糖核酸酶A和脱氧核糖核酸酶I敏感的位点，并且通过用任何一种酶消化都能迅速从细胞核中释放出来。
