Department of Nursing, Shanxi Provincial People's Hospital, Taiyuan, China.
Department of Respiratory and Critical Care Medicine, Liaocheng People's Hospital, Liaocheng, Shandong, China.
BMJ Open. 2023 Oct 11;13(10):e068683. doi: 10.1136/bmjopen-2022-068683.
The aim of this study was to explore the effect of depression on pain, disease activity, functional disability and health-related quality of life measured by Visual Analogue Scale, Systemic Lupus Erythematosus Disease Activity Index, Health Assessment Questionnaire and Short Form-36 in patients with systemic lupus erythematosus.
Meta-analysis.
The PubMed, EMBASE, Cochrane Library and Web of Science were searched for obtaining available studies from inception to 7 March 2023.
Studies evaluating the impact of depression on pain, disease activity, functional disability and quality of life were included.
Two authors independently screened publications and extracted data according to set inclusion and exclusion criteria. Statistical analyses were conducted with RevMan V.5.3.0. Data were pooled using a fixed-effects or random-effects model according to heterogeneity.
A total of 13 identified studies met the inclusion criteria, reporting on a total of 1911 patients with systemic lupus erythematosus. The Visual Analogue Scale score was significantly higher in patients with depression than those without depression (standardised mean difference (SMD)=0.84 (95% CI 0.27 to 1.42), p=0.004). The Health Assessment Questionnaire score was significantly higher in patients with depression than those without depression (SMD=1.05 (95% CI 0.14 to 1.95), p<0.05). The Systemic Lupus Erythematosus Disease Activity Index score was significantly higher in patients with depression than those without depression (SMD=0.46 (95% CI 0.27 to 0.64), p<0.00001). Scores in most Short Form-36 dimensions (physical function, role physical function, emotional role function, vitality, mental health, social function, general health, physical component scale, mental component scale) were lower in patients with depression than those without depression.
This meta-analysis showed that depression was associated with increased in pain, functional disability and disease activity, and decline in health-related quality of life in patients with systemic lupus erythematosus. Awareness of the importance of the relationship between depression in systemic lupus erythematosus patients and pain, functional disability and the quality of life might assist rheumatology physicians and nurses in assessing and preventing these symptoms.
CRD42021265694.
本研究旨在探讨抑郁对系统性红斑狼疮患者疼痛、疾病活动度、功能障碍和健康相关生活质量（采用视觉模拟量表、系统性红斑狼疮疾病活动指数、健康评估问卷和简化 36 健康调查量表评估）的影响。
荟萃分析。
从建库至 2023 年 3 月 7 日，检索 PubMed、EMBASE、Cochrane 图书馆和 Web of Science，以获取可用的研究。
纳入评估抑郁对疼痛、疾病活动度、功能障碍和生活质量影响的研究。
两名作者根据设定的纳入和排除标准独立筛选出版物并提取数据。采用 RevMan V.5.3.0 进行统计学分析。根据异质性，采用固定效应或随机效应模型进行数据合并。
共纳入 13 项符合标准的研究，共纳入 1911 例系统性红斑狼疮患者。抑郁患者的视觉模拟量表评分明显高于无抑郁患者（标准化均数差（SMD）=0.84（95%CI 0.27 至 1.42），p=0.004）。抑郁患者的健康评估问卷评分明显高于无抑郁患者（SMD=1.05（95%CI 0.14 至 1.95），p<0.05）。抑郁患者的系统性红斑狼疮疾病活动指数评分明显高于无抑郁患者（SMD=0.46（95%CI 0.27 至 0.64），p<0.00001）。在大多数简化 36 健康调查量表维度（身体功能、身体角色功能、情感角色功能、活力、心理健康、社会功能、总体健康、生理成分量表、心理成分量表）中，抑郁患者的评分均低于无抑郁患者。
这项荟萃分析表明，抑郁与系统性红斑狼疮患者的疼痛、功能障碍和疾病活动度增加以及健康相关生活质量下降有关。了解系统性红斑狼疮患者抑郁与疼痛、功能障碍和生活质量之间关系的重要性，可能有助于风湿病医生和护士评估和预防这些症状。
CRD42021265694。
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