Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Student research committee, Shiraz University of medical sciences, Shiraz, Iran.
J Cosmet Dermatol. 2024 Feb;23(2):600-606. doi: 10.1111/jocd.16004. Epub 2023 Oct 11.
With increasing age, patients' facial volume decrease. For this reason, nano fat grafting has recently gained popularity as adjunctive treatment to facial rejuvenation procedures. However, few quantitative studies have been conducted to investigate the impact of nano fat on facial wrinkles.
In the present study, authors aim to investigate the therapeutic effect of intradermal injection of nano fat on fine facial wrinkles and assess their changes over 7 months of follow-up.
In this randomized trial, 15 patients with fine facial wrinkles were enrolled. The fat was harvested from the abdomen and processed into nano fat. Nano fat was injected into the facial wrinkles intradermally with a needle of 27 gauge. The patients were evaluated before and 7 months postinjection utilizing Visio face 1000D (CK electronic, manufactured in Germany); and four parameters of wrinkles (area, volume, depth, and percent area) were evaluated before and after the nano fat injection.
Our evaluation with Visio face showed that nano fat injection was significantly reduced the volume, area, depth, and percent area of wrinkles after 7 months of follow-up without serious long-lasting adverse effects. Moreover, wrinkles with higher percent area, depth and volume loss show greater improvement after the treatment. Our results also indicate that males and females equally benefit from this treatment except for the percent area parameter that was improved more significantly in male patients.
Our study showed that intradermal injection of nano fat significantly decreases the volume, area, depth, and percent area of fine facial wrinkles. Further quantitative studies with control groups and larger sample sizes are required.
随着年龄的增长，患者的面部体积会减少。因此，纳米脂肪移植最近作为面部年轻化手术的辅助治疗方法越来越受欢迎。然而，很少有定量研究来探讨纳米脂肪对面部皱纹的影响。
本研究旨在探讨真皮内注射纳米脂肪对细小面部皱纹的治疗效果，并评估其在 7 个月随访期间的变化。
在这项随机试验中，纳入了 15 名有细小面部皱纹的患者。脂肪从腹部采集并加工成纳米脂肪。用 27 号针将纳米脂肪皮内注射到面部皱纹中。在注射前和注射后 7 个月，利用 Visio face 1000D（CK electronic，德国制造）对患者进行评估；并评估皱纹的四个参数（面积、体积、深度和面积百分比）在纳米脂肪注射前后的变化。
我们用 Visio face 的评估显示，纳米脂肪注射在 7 个月的随访后显著减少了皱纹的体积、面积、深度和面积百分比，没有严重的持久不良反应。此外，面积百分比、深度和体积损失较高的皱纹在治疗后改善更明显。我们的结果还表明，男性和女性都能从这种治疗中受益，除了男性患者的面积百分比参数改善更为显著。
我们的研究表明，真皮内注射纳米脂肪可显著减少细小面部皱纹的体积、面积、深度和面积百分比。需要进行有对照组和更大样本量的进一步定量研究。
