Neurology Section, Hospital Universitari de Bellvitge (HUB), Campus Bellvitge, L'Hospitalet de Llobregat, University of Barcelona - IDIBELL, Barcelona, Spain.
Cognition and Brain Plasticity Group [Bellvitge Biomedical Research Institute-IDIBELL], L'Hospitalet de Llobregat, Barcelona, Spain.
J Neuropsychol. 2024 Mar;18 Suppl 1:158-182. doi: 10.1111/jnp.12343. Epub 2023 Oct 12.
Cognitive performance influences the quality of life and survival of people with glioma. Thus, a detailed neuropsychological and language evaluation is essential. In this work, we tested if an analysis of errors in naming can indicate semantic and/or phonological impairments in 87 awake brain surgery patients. Secondly, we explored how language and cognition change after brain tumour resection. Finally, we checked if low-tumour grade had a protective effect on cognition. Our results indicated that naming errors can be useful to monitor semantic and phonological processing, as their number correlated with scores on tasks developed by our team for testing these domains. Secondly, we showed that - although an analysis at a whole group level indicates a decline in language functions - significantly more individual patients improve or remain stable when compared to the ones who declined. Finally, we observed that having LGG, when compared with HGG, favours patients' outcome after surgery, most probably due to brain plasticity mechanisms. We provide new evidence of the importance of applying a broader neuropsychological assessment and an analysis of naming errors in patients with glioma. Our approach may potentially ensure better detection of cognitive deficits and contribute to better postoperative outcomes. Our study also shows that an individualized approach in post-surgical follow-ups can reveal reassuring results showing that significantly more patients remain stable or improve and can be a promising avenue for similar reports. Finally, the study captures that plasticity mechanisms may act as protective in LGG versus HGG after surgery.
认知表现会影响脑胶质瘤患者的生活质量和生存。因此，详细的神经心理学和语言评估至关重要。在这项工作中，我们测试了在 87 名清醒脑外科手术患者中，对命名错误进行分析是否可以指示语义和/或语音障碍。其次，我们探讨了语言和认知在脑肿瘤切除后的变化。最后，我们检查了低肿瘤分级是否对认知有保护作用。我们的结果表明，命名错误可用于监测语义和语音处理，因为它们的数量与我们团队为测试这些领域而开发的任务得分相关。其次，我们表明 - 尽管在整个组水平的分析表明语言功能下降 - 与下降的患者相比，明显更多的患者改善或保持稳定。最后，我们观察到，与 HGG 相比，患有低级别胶质瘤（LGG）有利于手术后患者的预后，这可能是由于大脑的可塑性机制。我们提供了在脑胶质瘤患者中应用更广泛的神经心理学评估和命名错误分析的重要性的新证据。我们的方法可能有助于更好地检测认知缺陷，并有助于改善术后结果。我们的研究还表明，术后的个体化方法可能会显示出更稳定或改善的结果，这对类似报告来说是一个很有前途的途径。最后，该研究表明，在手术后，LGG 中的可塑性机制可能对 HGG 具有保护作用。
