Sonego Benedetta, Zelin Enrico, Zalaudek Iris, di Meo Nicola
Dermatology Clinic of Trieste, Maggiore Hospital, University of Trieste, Italy.
Dermatol Reports. 2023 Jun 6;15(3):9676. doi: 10.4081/dr.2023.9676. eCollection 2023 Sep 12.
Bullous pemphigoid (BP) is an autoimmune disease with a chronic relapsing course, predominantly affecting elderly people. Drugs are one of the possible triggers. A class of antidiabetic drugs often associated with the development of BP are inhibitors of dipeptidyl peptidase 4 (DPP-4 inhibitors or gliptins), while less known is the association with glucagon-like-peptide-1 receptor agonists. We describe a case of BP caused by dulaglutide and summarize the other few cases described in the literature. As a class of drugs widely used in clinical practice, it is important to know about this possible adverse event.
大疱性类天疱疮（BP）是一种具有慢性复发病程的自身免疫性疾病，主要影响老年人。药物是可能的诱发因素之一。一类常与BP发生相关的抗糖尿病药物是二肽基肽酶4抑制剂（DPP-4抑制剂或格列汀类药物），而与胰高血糖素样肽-1受体激动剂的关联则鲜为人知。我们报告一例由度拉糖肽引起的BP病例，并总结文献中描述的其他少数病例。作为一类在临床实践中广泛使用的药物，了解这种可能的不良事件很重要。
