Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, .
Department of Nuclear Medicine, University Hospital Essen, .
Nucl Med Commun. 2023 Dec 1;44(12):1106-1113. doi: 10.1097/MNM.0000000000001774. Epub 2023 Oct 12.
To evaluate a correlation between an MRI-specific marker for cellular density [apparent diffusion coefficient (ADC)] and the expression of Somatostatin Receptors (SSTR) in patients with meningioma of the skull plane and orbital space.
68 Ga-DOTATOC PET/MR imaging was performed in 60 Patients with suspected or diagnosed meningiomas of the skull base and eye socket. Analysis of ADC values succeeded in 32 patients. ADC values (ADC mean and ADC min ) were analyzed using a polygonal region of interest. Tracer-uptake of target lesions was assessed according to corresponding maximal (SUV max ) and mean (SUV mean ) values. Correlations between assessed parameters were evaluated using the Pearson correlation coefficient.
One out of 32 patients (3%) was diagnosed with lymphoma by histopathological examination and therefore excluded from further analysis. Median ADC mean amounted to 822 × 10 -5 mm²/s -1 (95% CI: 570-1497) and median ADC min was 493 × 10 -5 mm 2 /s -1 (95% CI: 162-783). There were no significant correlations between SUV max and ADC min (r = 0.60; P = 0.76) or ADC mean (r = -0.52; P = 0.79), respectively. However, Pearson's test showed a weak, inverse but insignificant correlation between ADC mean and SUV mean (r = -0.33; P = 0.07).
The presented data displays no relevant correlations between increased SSTR expression and cellularity in patients with meningioma of the skull base. SSTR-PET and DWI thus may offer complementary information on tumor characteristics of meningioma.
评估 MRI 特定的细胞密度标志物（表观扩散系数 [ADC]）与颅底和眼眶脑膜瘤患者生长抑素受体（SSTR）表达之间的相关性。
对 60 例疑似或诊断为颅底和眼眶脑膜瘤的患者进行 68Ga-DOTATOC PET/MR 成像。在 32 例患者中成功分析了 ADC 值。使用多边形感兴趣区分析 ADC 值（ADC 平均值和 ADC 最小值）。根据相应的最大（SUV max）和平均（SUV mean）值评估靶病变的示踪剂摄取。使用 Pearson 相关系数评估评估参数之间的相关性。
1 例患者（3%）经组织病理学检查诊断为淋巴瘤，因此排除在进一步分析之外。ADC 平均值中位数为 822×10-5mm2/s-1（95%CI：570-1497），ADC 最小值中位数为 493×10-5mm2/s-1（95%CI：162-783）。SUV max 与 ADC min（r=0.60；P=0.76）或 ADC mean（r=-0.52；P=0.79）之间无显著相关性。然而，Pearson 检验显示 ADC mean 与 SUV mean 之间存在微弱、负相关但无统计学意义的相关性（r=-0.33；P=0.07）。
所提供的数据显示，颅底脑膜瘤患者中 SSTR 表达增加与细胞密度之间无明显相关性。SSTR-PET 和 DWI 因此可能提供脑膜瘤肿瘤特征的互补信息。
